| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2155872 | B | Inhibition of leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes by UV spectroscopy | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA997007 | B | Inhibition of CYP4F2-mediated gamma-tocopherol metabolism in human HepG2/C3A cells preincubated for 4 hrs and continued for 48 hrs | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA997008 | B | Inhibition of CYP4F2-mediated gamma-tocopherol metabolism in human HepG2/C3A cells at 1 uM preincubated for 6 hrs and continued for 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA997011 | B | Inhibition of CYP4F2-mediated gamma-tocopherol metabolism in human HepG2/C3A cells at 20 nM preincubated for 4 hrs and continued for 48 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA997012 | B | Inhibition of CYP4F2-mediated gamma-tocopherol metabolism in human HepG2/C3A cells at 1.0 uM preincubated for 4 hrs and continued for 48 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3509252 | A | Enzyme kinetics constant (Km value) for CYP4F2 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 7. | ALA3509261 | A | Enzyme kinetics constant (Vmax value) for CYP4F2 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 8. | ALA3509270 | A | Metabolic clearance (ul.min.nmol-1 CYP) of aliskiren hemifumarate for CYP4F2 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 9. | ALA3536993 | A | Activity at human recombinant CYP4F2-mediated drug metabolism treated with 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3537358 | A | Prodrug conversion assessed as human recombinant CYP4F2-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3537258 | A | Activity at human recombinant CYP4F2 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation at 50 uM by HPLC-RA analysis in presence of anti-CYP4F2 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3532910 | A | Inhibition of human recombinant CYP4F2 assessed as fingolimod metabolism | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3532911 | A | Inhibition of human CYP4F2 in human liver microsomes assessed as fingolimod metabolism | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA3535835 | A | Activity at human recombinant CYP4F2 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation after 15 mins by Eadie-Hofstee plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3535836 | A | Activity at human recombinant CYP4F2 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation after 15 mins measured per nmol of P450 by Eadie-Hofstee plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3535837 | A | Activity at human recombinant CYP4F2 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as intrinsic clearance for metabolite formation after 15 mins measured per nmol of P450 by Eadie-Hofstee plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3535848 | A | Activity at human recombinant CYP4F2 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes at 10 uM by HPLC-RA analysis in presence of CYP4F2 and CYP4F12 inhibitor ketoconazole | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3532998 | A | Activity at human recombinant CYP4F2 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as relative abundance of compound formation treated with [14C]fingolimod at 100 uM after 30 mins by HPLC-RA analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA3532135 | A | Activity of human recombinant CYP4F2 assessed as enzyme-mediated drug metabolism treated with 25 uM vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3529776 | A | Activity of human recombinant CYP4F2 assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature |
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