# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2388873 | Binding | Agonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assay | Homo sapiens | 1 | ALA2384924 | cell-based format | Scientific Literature | |
2. | ALA2388874 | Binding | Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment at 10 uM incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay | Homo sapiens | 29 | ALA2384924 | cell-based format | Scientific Literature | |
3. | ALA2388875 | Binding | Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay | Homo sapiens | 35 | ALA2384924 | cell-based format | Scientific Literature | |
4. | ALA3124698 | Binding | Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay | Homo sapiens | 2 | ALA3120089 | cell-based format | Scientific Literature | |
5. | ALA3124699 | Binding | Antagonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 10 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay | Homo sapiens | 2 | ALA3120089 | cell-based format | Scientific Literature | |
6. | ALA3222491 | Binding | Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method relative to delta9-THC | Homo sapiens | 49 | ALA3217528 | cell-based format | Scientific Literature | |
7. | ALA3222508 | Binding | Competitive antagonist activity against human GPR18 expressed in CHO cells assessed as induction of parallel rightward shift of concentration response curve of delta9-THC-induced beta-arrestin recruitment at 3 uM by beta-galactosidase enzyme fragment complementation method | Homo sapiens | 1 | ALA3217528 | cell-based format | Scientific Literature | |
8. | ALA3222509 | Binding | Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay | Homo sapiens | 1 | ALA3217528 | cell-based format | Scientific Literature | |
9. | ALA3222511 | Binding | Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method | Homo sapiens | 3 | ALA3217528 | cell-based format | Scientific Literature | |
10. | ALA3222808 | Binding | Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment at 10 uM by beta-galactosidase enzyme fragment complementation method | Homo sapiens | 40 | ALA3217528 | cell-based format | Scientific Literature | |
11. | ALA3222809 | Binding | Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method | Homo sapiens | 51 | ALA3217528 | cell-based format | Scientific Literature | |
12. | ALA4155949 | Functional | Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay | Homo sapiens | 33 | ALA4152303 | cell-based format | Scientific Literature | |
13. | ALA4155950 | Functional | Agonist activity at recombinant human GPR18 expressed in CHO cells assessed as increase in beta-arrestin recruitment incubated for 60 mins measured for 1 sec by luminescence assay | Homo sapiens | 33 | ALA4152303 | cell-based format | Scientific Literature | |
14. | ALA4155955 | Functional | Competitive antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay | Homo sapiens | 1 | ALA4152303 | cell-based format | Scientific Literature | |
15. | ALA4155956 | Functional | Agonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassay | Homo sapiens | 1 | ALA4152303 | cell-based format | Scientific Literature | |
16. | ALA4155957 | Functional | Agonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysis | Homo sapiens | 1 | ALA4152303 | cell-based format | Scientific Literature | |
17. | ALA4731299 | Binding | Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis | Homo sapiens | 18 | ALA4725451 | cell-based format | Scientific Literature | |
18. | ALA4731300 | Binding | Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase based topcount luminescence analysis relative to control | Homo sapiens | 15 | ALA4725451 | cell-based format | Scientific Literature | |
19. | ALA4731301 | Binding | Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring efficacy at 10 uM after 90 mins by beta-galactosidase based topcount luminescence analysis relative to delta9-tetrahydrocannabinol | Homo sapiens | 3 | ALA4725451 | cell-based format | Scientific Literature | |
20. | ALA4731302 | Functional | Antagonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as inhibition of THC-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis | Homo sapiens | 19 | ALA4725451 | cell-based format | Scientific Literature |