| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2405217 | B | Activation of ClC-3 in human CNE2Z cells assessed as increase in chloride current in outward and inward direction at +80mV holding potential at 1 uM by whole-cell patch clamp method | Homo sapiens | 2 | ALA2401713 | cell-based format | Scientific Literature | |
| 2. | ALA2405218 | B | Activation of ClC-3 in SV40-transformed human NP69 cells assessed as increase in chloride current density at +80mV holding potential at 1 uM by whole-cell patch clamp method | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 3. | ALA2405221 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of Akt at Thr308 at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 4. | ALA2405222 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of m-TOR at ser2481 at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 5. | ALA2405223 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of m-TOR at ser2448 at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 6. | ALA2405224 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in m-TOR level at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 7. | ALA2405225 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of Akt at ser473 at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 8. | ALA2405226 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in Akt level at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 9. | ALA2405227 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in PI3K P110alpha level at 1 uM after 24 hrs by Western blot analysis in presence of ClC-3 siRNA | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 10. | ALA2405386 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of m-TOR at ser2481 at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 11. | ALA2405387 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of m-TOR at ser2448 at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 12. | ALA2405388 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in m-TOR level at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 13. | ALA2405389 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of Akt at Thr308 at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 14. | ALA2405390 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in phosphorylation of Akt at ser473 at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 15. | ALA2405391 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in PI3K P110alpha level at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 16. | ALA2405392 | B | Activation of ClC-3 in human CNE2Z cells assessed as decrease in Akt level at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 17. | ALA2405585 | B | Activation of ClC-3 in human CNE2Z cells assessed as increase in chloride current in outward and inward direction at +80mV holding potential at 1 uM by whole-cell patch clamp method in presence of NPPB and tamoxifen | Homo sapiens | 1 | ALA2401713 | cell-based format | Scientific Literature | |
| 18. | ALA2405586 | B | Activation of ClC-3 in human CNE2Z cells assessed as increase in chloride current density at +80mV holding potential at 1 uM by whole-cell patch clamp method relative to vehicle-treated control | Homo sapiens | 5 | ALA2401713 | cell-based format | Scientific Literature |
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