| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1941459 | B | Inhibition of JAK1/JAK3 in human PBMC assessed as inhibition of IL2-stimulated STATs phosphorylation preincubated for 30 mins prior to IL2 challenge measured after 15 mins by intracellular phosflow staining | Homo sapiens | 6 | ALA1938231 | cell-based format | Scientific Literature | |
| 2. | ALA1941462 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as inhibition of IL2-stimulated STATs phosphorylation preincubated for 30 mins prior to IL2 challenge measured after 15 mins by intracellular phosflow staining | Homo sapiens | 6 | ALA1938231 | cell-based format | Scientific Literature | |
| 3. | ALA2329054 | B | Inhibition of JAK3/JAK1 in human PBMC expressing CD3 assessed as inhibition of IL-2-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 9 | ALA2321829 | protein complex format | Scientific Literature | |
| 4. | ALA2329555 | B | Inhibition of JAK3/JAK1 in human whole blood expressing CD13 assessed as inhibition of IL-2-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 9 | ALA2321829 | tissue-based format | Scientific Literature | |
| 5. | ALA2378510 | B | Inhibition of JAK3/1 in human T cells expressing CD3 assessed as inhibition of IL2-stimulated STAT5a phosphorylation | Homo sapiens | 11 | ALA2375236 | cell-based format | Scientific Literature | |
| 6. | ALA2378979 | B | Inhibition of JAK1/3 in human PBMC expressing CD3 assessed as inhibition of IL2-induced STAT5a phosphorylation | Homo sapiens | 4 | ALA2375291 | protein complex format | Scientific Literature | |
| 7. | ALA3299204 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as inhibition of IL-15-induced STAT-5 phosphorylation preincubated for 45 mins followed by IL-15 addition measured after 15 mins by FACS analysis | Homo sapiens | 5 | ALA3297690 | protein complex format | Scientific Literature | |
| 8. | ALA3382726 | B | Inhibition of JAK1/JAK3 in IL4-induced human THP1 cells assessed as pSTAT6 | Homo sapiens | 1 | ALA3351789 | cell-based format | Scientific Literature | |
| 9. | ALA3382727 | B | Inhibition of JAK1/JAK3 in IL2-induced human NK92 cells assessed as pSTAT5 | Homo sapiens | 1 | ALA3351789 | cell-based format | Scientific Literature | |
| 10. | ALA3376518 | B | Inhibition of JAK3/JAK1 in human PBMC expressing CD3 assessed as inhibition of IL-2-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 11 | ALA3351377 | protein complex format | Scientific Literature | |
| 11. | ALA3374518 | B | Inhibition of JAK1/3-induced STAT5 phosphorylation in IL-2-activated human DERL7 cells at 10 uM after 2 hrs by SDS-PAGE analysis | Homo sapiens | 1 | ALA3352511 | cell-based format | Scientific Literature | |
| 12. | ALA3624176 | B | Inhibition of JAK1/JAK3 in T cells (unknown origin) assessed as reduction in IL2-mediated cell proliferation | Homo sapiens | 1 | ALA3621135 | cell-based format | Scientific Literature | |
| 13. | ALA3766668 | B | Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL-21-induced STAT3 phosphorylation preincubated for 5 mins followed by IL-21 stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | ALA3763089 | protein complex format | Scientific Literature | |
| 14. | ALA4003466 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as inhibition of IL-4 induced STAT6 phosphorylation preincubated for 45 mins followed by Il-4 addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | ALA4002590 | protein complex format | Scientific Literature | |
| 15. | ALA4003510 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as inhibition of IL-4 induced STAT6 phosphorylation by measuring free compound concentration required for the effect preincubated for 45 mins followed by Il-4 addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | ALA4002590 | protein complex format | Scientific Literature | |
| 16. | ALA4023010 | B | Inhibition of JAK1/JAK3 in CD8+ human whole blood assessed as reduction in IL-15 induced STAT5 phosphorylation preincubated for 45 mins followed by IL-15 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | ALA4020822 | protein complex format | Scientific Literature | |
| 17. | ALA4023011 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-21 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-21 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | ALA4020822 | protein complex format | Scientific Literature | |
| 18. | ALA4047234 | B | Inhibition of JAK1/JAK3 in human PBMC derived T cell assessed as reduction in IL2-induced STAT3 phosphorylation after 30 mins by ELISA | Homo sapiens | 1 | ALA4043231 | protein complex format | Scientific Literature | |
| 19. | ALA4054824 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISA | Homo sapiens | 33 | ALA4052645 | protein complex format | Scientific Literature | |
| 20. | ALA4124199 | B | Inhibition of JAK1/JAK3 in human CD4 positive T cells assessed as inhibition of IL2-stimulated STAT5 phosphorylation at Tyr-695 residue at 50 to 300 nM preincubated for 1 hr followed by IL-2 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | ALA4118225 | cell-based format | Scientific Literature |
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