| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2329052 | B | Inhibition of JAK2/JAK1 in human PBMC expressing CD14 assessed as inhibition of IFN-gamma-stimulated STAT1 phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 9 | protein complex format | Scientific Literature | ||
| 2. | ALA2378508 | B | Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylation | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 3. | ALA2378972 | B | Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylation | Homo sapiens | 4 | protein complex format | Scientific Literature | ||
| 4. | ALA3382729 | B | Inhibition of JAK1/JAK2 in OSM-induced human HeLa cells assessed as STAT1 reporter | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3382730 | B | Inhibition of JAK1/JAK2 in IFNgamma-induced human THP1 cells assessed as pSTAT1 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3390782 | B | Inhibition of JAK1/2 (unknown origin) | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 7. | ALA3377097 | B | Inhibition of JAK2/JAK1 in human PBMC expressing CD14 assessed as inhibition of IFN-gamma-stimulated STAT1 phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 11 | protein complex format | Scientific Literature | ||
| 8. | ALA4003467 | B | Inhibition of JAK1/JAK2 in human whole blood assessed as inhibition of IL-6 induced STAT3 phosphorylation preincubated for 45 mins followed by Il-6 addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 9. | ALA4003511 | B | Inhibition of JAK1/JAK2 in human whole blood assessed as inhibition of IL-6 induced STAT3 phosphorylation by measuring free compound concentration required for the effect preincubated for 45 mins followed by Il-6 addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 10. | ALA4023007 | B | Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IFNgamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFNgamma addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 11. | ALA4023012 | B | Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 12. | ALA4031362 | B | Inhibition of JAK1/JAK2 in human KMS-12-BM cells assessed as decrease in IL6-induced phosphorylation of STAT3 up to 3 uM preincubated for 3 hrs followed by IL-6 addition measured after 10 mins by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4031363 | B | Inhibition of JAK1/JAK2 in human MOLM14 cells assessed as decrease in IL6-induced phosphorylation of STAT3 up to 0.5 uM preincubated for 3 hrs followed by IL-6 addition measured after 10 mins by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4377395 | A | Inhibition of JAK1/JAK2 in in human whole blood assessed as decrease in IL6-induced STAT3 phosphorylation in CD3+ T cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4411583 | B | Inhibition of JAK1/JAK2 signaling pathway in human CD14 +ve cells of whole blood assessed as reduction in IFN-gamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN-gamma addition and measured measured after 15 mins by FACS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4411584 | B | Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed by IL-6 addition and measured measured after 15 mins by FACS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4411585 | B | Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-6 addition and measured measured after 15 mins by FACS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4411591 | B | Inhibition of JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 addition and measured measured after 15 mins by FACS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4414792 | A | Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 20. | ALA4620441 | B | Inhibition of JAK1/JAK2 in human whole blood assessed as free fraction of IL6-induced STAT1 phosphorylation by flow cytometry | Homo sapiens | 1 | tissue-based format | Scientific Literature |
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