| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1794400 | B | PUBCHEM_BIOASSAY: Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504540] | 118 | ALA1201862 | biochemical format | PubChem BioAssays | ||
| 2. | ALA2382888 | B | Inhibition of Keap1-Nrf2 interaction in human U2OS cells assessed as Nrf2 nuclear translocation by beta-lactamase reporter assay | Homo sapiens | 3 | ALA2380257 | cell-based format | Scientific Literature | |
| 3. | ALA2382889 | B | Inhibition of Keap1-Nrf2 interaction in human HepG2 cells expressing ARE-bla assessed as activation of antioxidant response element by beta-lactamase reporter assay | Homo sapiens | 3 | ALA2380257 | cell-based format | Scientific Literature | |
| 4. | ALA2382891 | B | Inhibition of Keap1-Nrf2 interaction (unknown origin) after 30 mins by fluorescence polarization assay | Homo sapiens | 1 | ALA2380257 | protein format | Scientific Literature | |
| 5. | ALA2412480 | B | Induction of Nrf2/Keap1 in human HCT116 cells assessed as induction of ARE activity at 20 uM after 12 hrs by luciferase reporter gene assay in presence of MEK1/2 inhibitor PD98059 | Homo sapiens | 1 | ALA2406970 | cell-based format | Scientific Literature | |
| 6. | ALA2412487 | B | Induction of Nrf2/Keap1 in human HCT116 cells assessed as induction of ARE activity after 12 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA2406970 | cell-based format | Scientific Literature | |
| 7. | ALA2412488 | B | Induction of Nrf2/Keap1 in human HCT116 cells assessed as induction of ARE activity at 80 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 1 | ALA2406970 | cell-based format | Scientific Literature | |
| 8. | ALA2412489 | B | Induction of Nrf2/Keap1 in human HCT116 cells assessed as induction of ARE activity at 20 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 26 | ALA2406970 | cell-based format | Scientific Literature | |
| 9. | ALA2412490 | B | Induction of Nrf2/Keap1 in human HCT116 cells assessed as induction of ARE activity at 50 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 26 | ALA2406970 | cell-based format | Scientific Literature | |
| 10. | ALA3239747 | B | Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotropy assay | Homo sapiens | 54 | ALA3232949 | protein format | Scientific Literature | |
| 11. | ALA3424043 | B | Inhibition of Keap1/Nrf2 complex (unknown origin) | Homo sapiens | 3 | ALA3421567 | protein format | Scientific Literature | |
| 12. | ALA3424044 | B | Binding affinity to Keap1/Nrf2 complex (unknown origin) by fluorescence polarization assay | Homo sapiens | 4 | ALA3421567 | protein format | Scientific Literature | |
| 13. | ALA3424045 | B | Binding affinity to Keap1/Nrf2 complex (unknown origin) by ITC method | Homo sapiens | 2 | ALA3421567 | protein format | Scientific Literature | |
| 14. | ALA3602922 | B | Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction by fluorescence polarization assay | Homo sapiens | 1 | ALA3600323 | protein format | Scientific Literature | |
| 15. | ALA3602923 | B | Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competition assay | Homo sapiens | 21 | ALA3600323 | protein format | Scientific Literature | |
| 16. | ALA3602926 | B | Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as induction of Nrf2 activation at 0.1 uM incubated for 12 hrs by ARE-luciferase reporter gene assay relative to untreated control | Homo sapiens | 15 | ALA3600323 | cell-based format | Scientific Literature | |
| 17. | ALA3602992 | B | Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as induction of Nrf2 activation at 1 uM incubated for 12 hrs by ARE-luciferase reporter gene assay relative to untreated control | Homo sapiens | 15 | ALA3600323 | cell-based format | Scientific Literature | |
| 18. | ALA3602993 | B | Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2-ARE-C8 cells assessed as induction of Nrf2 activation at 5 uM incubated for 12 hrs by ARE-luciferase reporter gene assay relative to untreated control | Homo sapiens | 15 | ALA3600323 | cell-based format | Scientific Literature | |
| 19. | ALA3602994 | B | Inhibition of Keap1-Nrf2 protein-protein interaction in human HCT116 cells assessed as increase in HO1 protein expression at 1 to 20 uM incubated for 6 hrs by Western blotting method | Homo sapiens | 1 | ALA3600323 | cell-based format | Scientific Literature | |
| 20. | ALA3602995 | B | Inhibition of Keap1-Nrf2 protein-protein interaction in human HCT116 cells assessed as increase in gamma-GCS protein expression at 1 to 20 uM incubated for 6 hrs by Western blotting method | Homo sapiens | 1 | ALA3600323 | cell-based format | Scientific Literature |
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