| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2427687 | B | Inhibition of GluN1/GluN2C receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at 3 uM by two-electrode voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA3594732 | B | Inhibition of recombinant GluN1/GluN2C receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whole-cell voltage-clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3801522 | B | Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3801523 | B | Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3871167 | B | Positive allosteric modulation of GluN1/GluN2C receptor (unknown origin) assessed as increase in glutamate-induced calcium flux measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 6. | ALA3871168 | B | Positive allosteric modulation of GluN1/GluN2C receptor (unknown origin) assessed as increase in glutamate-induced calcium flux at 125 uM measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 7. | ALA4309027 | B | Negative allosteric modulation of GluN1a/GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glycine-induced channel current at -60 mV holding potential by two electrode voltage clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4339651 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4835978 | B | Positive allosteric modulation of GluN1/GluN2C (unknown origin) expressed in HEK293 cells assessed as enhancement of current induced by NDMA and glycine at 30 uM by whole-cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5132338 | B | Antagonist activity at GluN1/GluN2C NMDA receptor (unknown origin) transfected in HEK293 cells assessed as inhibition of glycine induced current response at 10 uM in presence of L-glutamate by patch-clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5136765 | B | Positive allosteric modulation of recombinant human GluN1/GluN2C receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5136767 | B | Positive allosteric modulation of recombinant human GluN1/GluN2C receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5145396 | B | Positive allosteric modulator activity at GluN1a/GluN2C (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5145421 | B | Positive allosteric modulator activity at GluN1a/GluN2C (unknown origin) expressed in CHO cells at 30 uM in presence of glutamate by Ca2+ influx assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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