| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2378352 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 0.001 uM after 24 hrs by ELISA in presence of lipid IVa in presence of 0.1 uM of lipid IVa | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 2. | ALA2378353 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as TNF-alpha release at 0.001 uM after 24 hrs by ELISA in presence of 0.1 uM of lipid IVa | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 3. | ALA2378354 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 0.1 uM after 24 hrs by ELISA in presence of lipid IVa in presence of 0.1 uM of lipid IVa | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 4. | ALA2378355 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as TNF-alpha release at 0.1 uM after 24 hrs by ELISA in presence of 0.1 uM of lipid IVa | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 5. | ALA2378356 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 0.1 uM after 24 hrs by ELISA in presence of lipid IVa in presence of 0.5 uM of lipid IVa | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 6. | ALA2378357 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as TNF-alpha release at 0.1 uM after 24 hrs by ELISA in presence of 0.5 uM of lipid IVa | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 7. | ALA2378358 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 10'-4 uM after 24 hrs by ELISA | Homo sapiens | 1 | ALA2375239 | cell-based format | Scientific Literature | |
| 8. | ALA2378359 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 10'-3 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 9. | ALA2378360 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as TNF-alpha release at 10'-3 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 10. | ALA2378361 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 10 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 11. | ALA2378362 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-6 release at 10 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 12. | ALA2378363 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as TNF-alpha release at 10 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 13. | ALA2378364 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-1beta release at 0.1 uM to 1 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 14. | ALA2378365 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as IL-6 release at 0.1 uM to 1 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 15. | ALA2378366 | B | Agonist activity at TLR4/MD-2 receptor complex in human THP1 cells assessed as TNF-alpha release at 0.1 uM to 1 uM after 24 hrs by ELISA | Homo sapiens | 3 | ALA2375239 | cell-based format | Scientific Literature | |
| 16. | ALA3386489 | B | Activation of human TLR4/MD2 complex expressed in HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay | Homo sapiens | 1 | ALA3352206 | cell-based format | Scientific Literature | |
| 17. | ALA3386491 | B | Activation of human TLR4/MD2 complex expressed in CD14-deficient HEK293 Blue cells assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay | Homo sapiens | 1 | ALA3352206 | cell-based format | Scientific Literature | |
| 18. | ALA3386493 | B | Activation of human TLR4/MD2 complex expressed in HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay in presence of Rhodobacter sphaeroides LPS | Homo sapiens | 1 | ALA3352206 | cell-based format | Scientific Literature | |
| 19. | ALA3386504 | B | Activation of human TLR4/MD2 complex in human THP1 cells assessed as induction of NFkappaB activation incubated for 18 hrs | Homo sapiens | 1 | ALA3352206 | cell-based format | Scientific Literature | |
| 20. | ALA3373551 | A | Activation of TLR4/MD2 (unknown origin) expressed in HEK293 cells co-expressing CD14 assessed as induction of MyD88-dependent NF-kappaB activity after 24 hrs by NF-kappaB SEAP reporter gene assay | Homo sapiens | 11 | ALA3352303 | cell-based format | Scientific Literature |
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