| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3096300 | B | Binding affinity to ATRD8 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | Homo sapiens | 56 | single protein format | Scientific Literature | ||
| 2. | ALA3242400 | B | Inhibition of recombinant human PARP-8 at 10 uM relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 3. | ALA3382575 | B | Inhibition of human recombinant PARP8 at 10 uM incubated for 1 hr using using NAD+, biotinylated NAD+ and activated DNA by luminescence based assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3382585 | B | Inhibition of human recombinant PARP8 at 100 uM incubated for 1 hr using using NAD+, biotinylated NAD+ and activated DNA by luminescence based assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4305049 | B | Inhibition of PARP8 (unknown origin) at 500 nM using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 6. | ALA4305055 | B | Inhibition of PARP8 (unknown origin) at 1 uM using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4311848 | B | Inhibition of GFP-tagged human PARP8 expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by chemiluminescent immunoprecipitation assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4322267 | B | Inhibition of human recombinant PARP8 by chemiluminescence method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4678526 | B | Inhibition of PARP-8 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4701310 | B | Inhibition of PARP8 (unknown origin) assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA5108310 | B | Inhibition of N-terminal His-tagged full length human PARP8 expressed in Escherichia coli BL21 (DE3) at 10 uM preincubated with 6-a-NAD+ for 5 to 10 mins followed by enzyme addition and measured after 60 mins using NAD+ as substrate byHRP based chemiluminescence assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 12. | ALA5124503 | B | Inhibition of PARP8 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA5152046 | B | Binding affinity to PARP8 (unknown origin) assessed as apparent dissociation constant | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 14. | ALA5228294 | B | Inhibition of human PARP8 by chemiluminescence assay | Homo sapiens | 1 | single protein format | Scientific Literature |
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