# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3111827 | B | Voltage dependent antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as reversible inhibition of icilin-induced whole-cell current at 100 uM by whole patch-clamp assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
2. | ALA3111828 | B | Voltage dependent antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as reversible inhibition of menthol-induced whole-cell current at 100 uM by whole patch-clamp assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
3. | ALA3111829 | B | Ratio of capsazepine IC50 for compound IC50 for TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellular Ca2+ influx | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
4. | ALA3111830 | B | Ratio of capsazepine IC50 for compound IC50 for TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
5. | ALA3112033 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at >100 uM by fluorescence-based assay | Mus musculus | 2 | ALA3108739 | cell-based format | Scientific Literature | |
6. | ALA3112184 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as reversible inhibition of cold-induced whole-cell current at 100 uM at -60 mV holding temperature by whole patch-clamp assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
7. | ALA3112185 | B | Reversible antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as reversible inhibition of icilin-induced whole-cell current at 100 uM at -60 mV holding temperature by whole patch-clamp assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
8. | ALA3112186 | B | Reversible antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as reversible inhibition of menthol-induced whole-cell current at 100 uM at -60 mV holding temperature by whole patch-clamp assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
9. | ALA3112187 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of cold-induced intracellular Ca2+ influx by Fluo-8 AM staining-based fluorescence analysis | Mus musculus | 2 | ALA3108739 | cell-based format | Scientific Literature | |
10. | ALA3112188 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of cold-induced intracellular Ca2+ influx at 100 uM by Fluo-4 AM staining-based fluorescence analysis | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
11. | ALA3112189 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at >500 uM by fluorescence-based assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
12. | ALA3112190 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at 10 to 100 uM by fluorescence-based assay | Mus musculus | 2 | ALA3108739 | cell-based format | Scientific Literature | |
13. | ALA3112191 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at >50 uM by fluorescence-based assay | Mus musculus | 2 | ALA3108739 | cell-based format | Scientific Literature | |
14. | ALA3112192 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at 0.3 to 10 uM by fluorescence-based assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
15. | ALA3112193 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at 3 to 30 uM by fluorescence-based assay | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
16. | ALA3112194 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx by fluorescence-based assay | Mus musculus | 6 | ALA3108739 | cell-based format | Scientific Literature | |
17. | ALA3112195 | B | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellular Ca2+ influx by fluorescence-based assay | Mus musculus | 6 | ALA3108739 | cell-based format | Scientific Literature | |
18. | ALA3112197 | B | Non-competitive antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at 5 to 100 uM by Schlid plot analysis | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
19. | ALA3112198 | B | Competitive antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of >300 uM menthol-induced intracellular Ca2+ influx at 5 to 100 uM by Schlid plot analysis | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature | |
20. | ALA3112199 | B | Antagonist activity at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx at 3 to 30 uM preincubated for 3 mins followed by icilin challenge measured after 10 mins of post compound washout | Mus musculus | 1 | ALA3108739 | cell-based format | Scientific Literature |