| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3111728 | B | Inhibition of SETD2 (unknown origin)-mediated incorporation of methyl group from [3H]-SAM into peptide substrate up to 50 uM by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA3420959 | B | Inhibition of human SETD2 (1347 to 1711) using histamine H3 (20 to 50) as substrate assessed as transfer of [3H]-Me of [3H-Me]-SAM to peptide substrate after 4 hrs by scintillation counting analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA3592403 | B | Inhibition of SETD2 (unknown origin) assessed as incorporation of tritium labeled methyl group from [3H]-SAM to substrate at 1 uM after 1 hr by scintillation proximity assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3784094 | B | Inhibition of human SETD2 at 10 and 50 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA3821904 | B | Inhibition of SETD2 (unknown origin) at 1 to 50 uM by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3859067 | B | Inhibition of SETD2 (unknown origin) at 50 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4005622 | B | Inhibition of SETD2 (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4005651 | B | Inhibition of SETD2 (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4195599 | B | Inhibition of recombinant human N-terminal GST-tagged SETD2 (1418 to 1714 residues) expressed in Escherichia coli at 10 uM relative to control | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 10. | ALA4346631 | B | Inhibition of SETD2 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4377310 | B | Inhibition of human SETD2 up to 50 uM using Biot-H3 (21-44) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4398082 | B | Inhibition of SETD2 (unknown origin) up to 50 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4411215 | B | Inhibition of SETD2 (unknown origin) at <5 uM using histone H3 peptide (21 to 44) as substrate in presence of co-factor SAM by LC-MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4480230 | B | Inhibition of N-terminal His6-tagged human SETD2 (1347 to 1711 residues) expressed in Escherichia coli Rosseta-2(DE3) cells assessed as residual activity at 50 uM using biotinylated-histone H3 (20 to 50 residues) as substrate in presence of [3H-Me]SAM by scintillation proximity assay relative to control | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 15. | ALA4731585 | B | Inhibition of recombinant human N-terminal GST-tagged SETD2 (1433 to 1711 residues) expressed in Escherichia coli using nucleosome as substrate at 10 uM by radiometric HotSpot assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA4827174 | B | Inhibition of SETD2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4833666 | B | Inhibition of SETD2 (unknown origin) at 10 uM using SAM as substrate measured up to 960 mins by AlphaScreen microplate reader assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA5030809 | B | Inhibition of SETD2 (unknown origin) at 1 to 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA5040787 | B | Inhibition of SETD2 (unknown origin) preincubated for 30 mins followed by SAM substrate addition measured after 2 hrs by plate reader method | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 20. | ALA5040788 | B | Binding affinity to SETD2 (unknown origin) by surface plasmon resonance | Homo sapiens | 1 | single protein format | Scientific Literature |
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