| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3111896 | B | Inhibition of PRMT8 (unknown origin)-mediated incorporation of methyl group from [3H]-SAM into peptide substrate up to 50 uM by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA3411810 | B | Displacement of [3H]-SAM from recombinant His6-tagged PRMT8 (unknown origin) expressed in Escherichia coli BL21(DE3) incubated for 5 mins prior to H4(1 to 20)-BTN peptide addition measured after 8 mins by scintillation proximity assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 3. | ALA3578943 | B | Inhibition of PRMT8 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3591483 | B | Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [3H]SAM and peptide mix | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 5. | ALA3592410 | B | Inhibition of PRMT8 (unknown origin) assessed as incorporation of tritium labeled methyl group from [3H]-SAM to substrate at 1 uM after 1 hr by scintillation proximity assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3784632 | B | Inhibition of human PRMT8 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA3803382 | B | Inhibition of PRMT8 (unknown origin) at 10 uM relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA3821903 | B | Inhibition of PRMT8 (unknown origin) at 1 to 50 uM by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3859041 | B | Inhibition of human PRMT8 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3859049 | B | Inhibition of PRMT8 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 11. | ALA3994771 | B | Inhibition of PRMT8 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA4005629 | B | Inhibition of PRMT8 (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4005658 | B | Inhibition of PRMT8 (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4013552 | B | Inhibition of recombinant human N-terminal FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 cell expression system using of histone H3 as substrate preincubated for 15 mins followed by substrate/S-adenosyl methionine addition measured after 60 mins by alpha LISA assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4026505 | B | Inhibition of PRMT8 (unknown origin) incubated for 15 mins followed by substrate addition measured after 60 mins by AlphaLisa method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4195596 | B | Inhibition of recombinant human N-terminal His/FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 cells at 10 uM relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4346588 | B | Covalent binding affinity to human PRMT8 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4346592 | B | Inhibition of human PRMT8 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA4346616 | B | Inhibition of PRMT8 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA4346647 | B | Inhibition of PRMT8 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 50 uM incubated for 1 hr by scintillation proximity assay relative to control | Homo sapiens | 2 | single protein format | Scientific Literature |
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