# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3111017 | B | Binding affinity to mouse Dnmt3A catalytic domain assessed as inhibition of AdoHcy binding at 0.85 mM by WaterLOGSY spectroscopic analysis | Mus musculus | 1 | ALA3108732 | single protein format | Scientific Literature | |
2. | ALA4625173 | B | Inhibition of murine DNMT3A catalytic domain-mediated DNA methylation using 5'-6FAM-tagged 30-mer duplex DNA (17 AT bp) as substrate preincubated for 30 mins followed by enzyme addition | Mus musculus | 2 | ALA4622935 | single protein format | Scientific Literature | |
3. | ALA4625174 | B | Inhibition of murine DNMT3A catalytic domain-mediated DNA methylation using 5'-6FAM-tagged 30-mer duplex DNA (22 AT bp) as substrate preincubated for 30 mins followed by enzyme addition | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
4. | ALA4625175 | B | Binding affinity to murine DNMT3A catalytic domain assessed as enzyme-DNA complex formation at 5 uM using 30-mer duplex DNA (17 AT bp) as substrate preincubated for 30 mins followed by enzyme addition by fluorescence polarization assay (Rvb = 0.9 +/- 0.1 uM) | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
5. | ALA4625176 | B | Binding affinity to murine DNMT3A catalytic domain assessed as enzyme-DNA complex formation at 15 uM using 30-mer duplex DNA (17 AT bp) as substrate preincubated for 30 mins followed by enzyme addition by fluorescence polarization assay (Rvb = 0.9 +/- 0.1 uM) | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
6. | ALA4625177 | B | Binding affinity to murine DNMT3A catalytic domain assessed as enzyme-DNA complex formation at 30 uM using 30-mer duplex DNA (17 AT bp) as substrate preincubated for 30 mins followed by enzyme addition by fluorescence polarization assay (Rvb = 0.9 +/- 0.1 uM) | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
7. | ALA4625178 | B | Binding affinity to murine DNMT3A catalytic domain assessed as enzyme-DNA complex formation at 5 uM using 30-mer duplex DNA (22 AT bp) as substrate preincubated for 30 mins followed by enzyme addition by fluorescence polarization assay (Rvb = 0.4 +/- 0.1 uM) | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
8. | ALA4625179 | B | Binding affinity to murine DNMT3A catalytic domain assessed as enzyme-DNA complex formation at 15 uM using 30-mer duplex DNA (22 AT bp) as substrate preincubated for 30 mins followed by enzyme addition by fluorescence polarization assay (Rvb = 0.4 +/- 0.1 uM) | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
9. | ALA4625180 | B | Binding affinity to murine DNMT3A catalytic domain assessed as enzyme-DNA complex formation at 30 uM using 30-mer duplex DNA (22 AT bp) as substrate preincubated for 30 mins followed by enzyme addition by fluorescence polarization assay (Rvb = 0.4 +/- 0.1 uM) | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
10. | ALA4625183 | B | Binding affinity to murine DNMT3A catalytic domain assessed as fold reduction in compound fluorescence at 5 uM by dialysis method relative to control | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature | |
11. | ALA4625184 | B | Inhibition of murine DNMT3A catalytic domain-mediated DNA methylation using 5'-6FAM-tagged 30-mer duplex DNA (17 AT bp) as substrate at 60 uM preincubated for 30 mins followed by enzyme addition relative to control | Mus musculus | 2 | ALA4622935 | single protein format | Scientific Literature | |
12. | ALA4625185 | B | Inhibition of murine DNMT3A catalytic domain-mediated DNA methylation using 5'-6FAM-tagged 30-mer duplex DNA (22 AT bp) as substrate at 60 uM preincubated for 30 mins followed by enzyme addition relative to control | Mus musculus | 1 | ALA4622935 | single protein format | Scientific Literature |