| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2150441 | B | Inhibition of TLR7/TLR8 in R848-stimulated mouse RAW264.7 cells at 0.6 uM after 24 hrs | Mus musculus | 1 | ALA2146360 | cell-based format | Scientific Literature | |
| 2. | ALA3116704 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-10 production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | ALA3112466 | protein format | Scientific Literature | |
| 3. | ALA3116705 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-12p40 production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | ALA3112466 | protein format | Scientific Literature | |
| 4. | ALA3116706 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-1beta production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | ALA3112466 | protein format | Scientific Literature | |
| 5. | ALA3116707 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of TNF-alpha production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | ALA3112466 | protein format | Scientific Literature | |
| 6. | ALA4235577 | B | Antagonist activity at TLR7/TLR8 in mouse BMDM assessed as inhibition of R848-stimulated TNFalpha production at 25 uM preincubated for 1 hr followed by R848 stimulation for 11 hrs by ELISA | Mus musculus | 2 | ALA4229513 | cell-based format | Scientific Literature | |
| 7. | ALA4825444 | B | Agonist activity at TLR7/8 in mouse RAW-blue cells assessed as immune activation by measuring induction of NFkappaB activation at 500 nM measured after 24 hrs by quanti-blue SEAP reporter gene-based assay | Mus musculus | 7 | ALA4823321 | cell-based format | Scientific Literature |
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