| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3111902 | B | Inhibition of MLL1/ASH2L/RBBP5/WDR5 complex (unknown origin)-mediated incorporation of methyl group from [3H]-SAM into peptide substrate up to 50 uM by scintillation proximity assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 2. | ALA3859787 | B | Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methylation after 60 mins by Alpha Screen assay | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 3. | ALA3859793 | B | Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 pLyss codon (+) assessed as decrease in methylation of Lys4 residue of histone H3 10-residue peptide using [3H]-S-adenosylmethionine as methyl donor preincubated for 2 to 5 mins with ASH2L/RBBP5/WDR5 followed by MLL1 addition measured after 30 mins by scintillation counting method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA3859795 | B | Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 pLyss codon (+) assessed as decrease in methylation of Lys4 residue of histone H3 10-residue peptide using [3H]-S-adenosylmethionine as methyl donor after 2 hrs by scintillation counting method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA3875501 | B | Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli BL21 (DE3) using 10-mer histone H3 peptide as substrate and [3H]-S-adenosyl methionine as cofactor after 2 hrs by scintillation counting method | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA3875504 | B | Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) at 30 uM by AlphaScreen assay relative to control | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 7. | ALA3875505 | B | Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay | Homo sapiens | 4 | protein complex format | Scientific Literature | ||
| 8. | ALA4411212 | B | Inhibition of MLL (MLL/ASH2L/RBBP5/WDR5) (unknown origin) at <5 uM using histone H3 peptide (1 to 21) as substrate in presence of co-factor SAM by LC-MS analysis | Homo sapiens | 1 | protein complex format | Scientific Literature |
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