| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1248011 | B | Inhibition of TLR7/TLR8-mediated IFN-gamma production in 3M-011-stimulated human PBMC at 100 uM after 20 hrs by ELISA | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 2. | ALA1248021 | B | Inhibition of TLR7/TLR8-mediated indoleamine 2,3-dioxygenase activation in 3M-011-stimulated human PBMC assessed as decrease in kynurenine to tryptophan level at 100 uM after 20 hrs by ELISA | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 3. | ALA1248025 | B | Inhibition of TLR7/TLR8-mediated upregulation of PDL1 expression in 3M-011-stimulated human PBMC at 100 uM after 20 hrs by flow cytometry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA3116568 | B | Agonist activity at TLR7/TLR8 in human PBMC assessed as induction of IFN-alpha production at 22.5 uM after 24 hrs by ELISA | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 5. | ALA3116569 | B | Agonist activity at TLR7/TLR8 in human PBMC assessed as induction of IFN-gamma production at 22.5 uM after 24 hrs by flow cytometric analysis | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 6. | ALA3116570 | B | Agonist activity at TLR7/TLR8 in human PBMC assessed as induction of TNF-alpha production at 22.5 uM after 24 hrs by flow cytometric analysis | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 7. | ALA4137750 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in IFNalpha2 levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4137751 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in CXCL10 levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4137752 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in IFNgamma levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4137753 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in TNFalpha levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4137754 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in IL-6 levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4137755 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in IL-1beta levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA4137756 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in MIP-1alpha levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4137757 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in MIP-1beta levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4137758 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in MCP1 levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA4137759 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in IL-12p40 levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4137760 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in IL-12p70 levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4137761 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in GROalpha levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4137762 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in VEGF levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4137763 | B | Agonist activity at TLR7/8 in human PBMCs co-cultured with primary human hepatocytes infected with HBV genotype C for 12 days assessed as increase in fractalkine sCD40L levels up to 5 uM measured after 42 days | Homo sapiens | 1 | assay format | Scientific Literature |
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