# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2150443 | B | Inhibition of TLR2/TLR6 in FSL1-stimulated mouse RAW264.7 cells at 0.6 uM after 24 hrs | Mus musculus | 1 | ALA2146360 | cell-based format | Scientific Literature | |
2. | ALA3111193 | B | Inhibition of TLR2/6-mediated NFkappaB p65 activation in BLP-stimulated BALB/c mouse BMDM at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 1 hr by TransAM ELISA | Mus musculus | 2 | ALA3108700 | protein complex format | Scientific Literature | |
3. | ALA3111194 | B | Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-6 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control | Mus musculus | 110 | ALA3108700 | protein complex format | Scientific Literature | |
4. | ALA3111195 | B | Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control | Mus musculus | 110 | ALA3108700 | protein complex format | Scientific Literature | |
5. | ALA3881377 | B | Antagonist activity at TLR2/6 in mouse RAW264.7 cells assessed as inhibition of FSL-1-induced receptor activation by measuring NO production at 3 uM after 24 hrs | Mus musculus | 1 | ALA3880440 | cell-based format | Patent Bioactivity Data | |
6. | ALA3881381 | B | Antagonist activity at TLR2/6 in mouse RAW264.7 cells assessed as inhibition of FSL-1-induced receptor activation by measuring NO production at 0.5 uM after 24 hrs | Mus musculus | 1 | ALA3880440 | cell-based format | Patent Bioactivity Data | |
7. | ALA4222362 | B | Antagonist activity at TLR2/TLR6 in mouse Raw 264.7 cells assessed as decrease in Pam2CSK4-induced iNOS levels at 40 uM after 24 hrs relative to positive control | Mus musculus | 1 | ALA4219143 | cell-based format | Scientific Literature | |
8. | ALA4361580 | B | Antagonist activity at TLR2/6 in mouse RAW264.7 cells assessed as reduction in FSL-1-induced TNFalpha secretion at 20 to 80 uM after 24 hrs by ELISA | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
9. | ALA5105459 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD40 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 6 | ALA5104121 | tissue-based format | Scientific Literature | |
10. | ALA5105460 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD86 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 3 | ALA5104121 | tissue-based format | Scientific Literature | |
11. | ALA5105461 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD40 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 6 | ALA5104121 | tissue-based format | Scientific Literature | |
12. | ALA5105462 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD86 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 3 | ALA5104121 | tissue-based format | Scientific Literature | |
13. | ALA5105463 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD40 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | ALA5104121 | tissue-based format | Scientific Literature | |
14. | ALA5105464 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD86 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | ALA5104121 | tissue-based format | Scientific Literature | |
15. | ALA5105465 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD40 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | ALA5104121 | tissue-based format | Scientific Literature | |
16. | ALA5105466 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD86 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | ALA5104121 | tissue-based format | Scientific Literature |