| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3129168 | B | Inhibition of human DNMT3A2/3L using unmethylated DNA as substrate in presence of [methyl-3H]-AdoMet | Homo sapiens | 6 | ALA3124813 | protein complex format | Scientific Literature | |
| 2. | ALA3418015 | B | Inhibition of His6-tagged human recombinant DNMT3A/DNMT3L expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method | Homo sapiens | 5 | ALA3414469 | cell-based format | Scientific Literature | |
| 3. | ALA3592285 | B | Inhibition of DNMT3A/3L (unknown origin) at 1 uM after 1 hr by filter-based assay | Homo sapiens | 1 | ALA3588844 | protein complex format | Scientific Literature | |
| 4. | ALA3626823 | B | Inhibition of DNMT3A/3L (unknown origin) using IDT-01 sequence 1/IDT-01 sequence 2 as substrate at 100 uM preincubated for 15 mins followed by substrate addition measured after 4 hrs by liquid scintillation counting analysis relative to control | Homo sapiens | 1 | ALA3621043 | protein complex format | Scientific Literature | |
| 5. | ALA3784082 | B | Inhibition of human DNMT3A/3L at 10 and 50 uM | Homo sapiens | 1 | ALA3779843 | protein complex format | Scientific Literature | |
| 6. | ALA3821910 | B | Inhibition of DNMT3A/3L (unknown origin) at 1 to 50 uM by TCA precipitation assay | Homo sapiens | 1 | ALA3817823 | protein complex format | Scientific Literature | |
| 7. | ALA3859055 | B | Inhibition of DNMT3A/3L (unknown origin) at 50 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA3856251 | protein complex format | Scientific Literature | |
| 8. | ALA4005634 | B | Inhibition of DNMT3A/3L (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by filter based assay | Homo sapiens | 1 | ALA4004823 | protein complex format | Scientific Literature | |
| 9. | ALA4005663 | B | Inhibition of DNMT3A/3L (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by filter based assay | Homo sapiens | 1 | ALA4004823 | protein complex format | Scientific Literature | |
| 10. | ALA4026508 | B | Inhibition of DNMT3A/3L (unknown origin) at 50 uM incubated for 15 mins followed by substrate addition measured after 60 mins by radioisotope assay | Homo sapiens | 1 | ALA4024748 | protein complex format | Scientific Literature | |
| 11. | ALA4026516 | B | Inhibition of DNMT3A/3L (unknown origin) at 100 uM incubated for 15 mins followed by substrate addition measured after 60 mins by radioisotope assay | Homo sapiens | 1 | ALA4024748 | protein complex format | Scientific Literature | |
| 12. | ALA4034609 | B | Inhibition of DNMT3A/3L (unknown origin) at 100 uM using biotinylated DNA oligonucleotides as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 4 hrs by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | protein complex format | Scientific Literature | |
| 13. | ALA4377325 | B | Inhibition of human DNMT3A/3L up to 50 uM using poly(dI-dC) as substrate and in presence of [3H]-SAM incubated for 1 hr by filter-based assay | Homo sapiens | 1 | ALA4376809 | protein complex format | Scientific Literature | |
| 14. | ALA4380692 | B | Inhibition of DNMT3a/3L (unknown origin) using poly(dIdC) as substrate at 5 uM incubated for 3 hrs in presence of 20 uM SAM by fluorescence analysis | Homo sapiens | 1 | ALA4376872 | protein complex format | Scientific Literature | |
| 15. | ALA4424252 | B | Inhibition of DNMT3A/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4422660 | protein complex format | Scientific Literature | |
| 16. | ALA4424254 | B | Non-competitive inhibition of DNMT3A/3L (unknown origin) after 1 hr in presence of DNA substrate and varying concentrations of SAM by scintillation proximity assay | Homo sapiens | 1 | ALA4422660 | protein complex format | Scientific Literature | |
| 17. | ALA4424255 | B | Non-competitive inhibition of DNMT3A/3L (unknown origin) after 1 hr in presence of SAM and varying concentrations of Poly dI-dC DNA substrate by scintillation proximity assay | Homo sapiens | 1 | ALA4422660 | protein complex format | Scientific Literature | |
| 18. | ALA4424257 | B | Inhibition of DNMT3A/3L (unknown origin) up to 1 mM using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay | Homo sapiens | 1 | ALA4422660 | protein complex format | Scientific Literature | |
| 19. | ALA4424258 | B | Steady state binding affinity to DNMT3A/3L (unknown origin) at 0.12 to 10 uM by SPR assay | Homo sapiens | 1 | ALA4422660 | protein complex format | Scientific Literature | |
| 20. | ALA4424259 | B | Binding affinity to DNMT3A/3L (unknown origin) assessed as active protein binding by SPR assay | Homo sapiens | 1 | ALA4422660 | protein complex format | Scientific Literature |
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