| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA829431 | B | KM value using Escherichia coli beta-glucuronidase obtained at 370 C in MOPS buffer of pH 7.0 | Escherichia coli | 2 | single protein format | Scientific Literature | ||
| 2. | ALA828630 | B | Vmax value using Escherichia coli beta-glucuronidase obtained at 370 C in MOPS buffer of pH 7.0 | Escherichia coli | 2 | single protein format | Scientific Literature | ||
| 3. | ALA3224083 | A | Prodrug activation in phosphate buffer assessed as Escherichia coli beta-glucuronidase-catalysed release of doxorubicin at 0.06 umol at pH 7 after 6 hrs by HPLC analysis | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 4. | ALA4275882 | A | Prodrug activation assessed as Escherichia coli beta-glucuronidase-mediated N2-((1r,4r)-4-aminocyclohexyl)-8-isopropyl-N4-(4-(pyridin-2-yl)benzyl)pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine formation after 20 hrs in presence of human serum albumin by HPLC-HRMS analysis | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4312560 | A | Drug metabolism assessed as Escherichia coli beta-glucuronidase-mediated PT2385 formation after 30 mins by LC-MS/MS analysis | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4334176 | B | Inhibition of Escherichia coli beta-glucuronidase at 1000 uM | Escherichia coli | 2 | single protein format | Scientific Literature | ||
| 7. | ALA4344593 | B | Inhibition of Escherichia coli GUS pre-incubated for 5 to 30 mins before 4-methylumbelliferone beta-D-glucuronide substrate addition at pH 5.5 | Escherichia coli | 6 | single protein format | Scientific Literature | ||
| 8. | ALA4344598 | B | Inhibition of Escherichia coli GUS pre-incubated for 5 to 30 mins before 4-methylumbelliferone beta-D-glucuronide substrate addition at pH 6.7 | Escherichia coli | 3 | single protein format | Scientific Literature | ||
| 9. | ALA4344604 | B | Inhibition of Escherichia coli GUS pre-incubated for 5 to 30 mins before 4-methylumbelliferone beta-D-glucuronide substrate addition at pH 3.6 to 6.9 | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4344605 | B | Inhibition of Escherichia coli GUS pre-incubated for 5 to 30 mins before 4-methylumbelliferone beta-D-glucuronide substrate addition at pH 6.5 to 7.9 | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4369568 | A | Prodrug conversion assessed as Escherichia coli beta-glucuronidase mediated MMAE formation after 5 hrs using albumin-conjugated compound by HPLC/HRMS analysis | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4611755 | B | Inhibition of Escherichia coli beta-glucuronidase using 4-methylumbelliferyl-beta-D-glucuronide hydrate as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence method | Escherichia coli | 5 | single protein format | Scientific Literature | ||
| 13. | ALA4611762 | B | Potency index, ratio of DSA IC50 to compound IC50 for inhibition of Escherichia coli beta-glucuronidase using 4-methylumbelliferyl-beta-D-glucuronide hydrate as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence method | Escherichia coli | 4 | single protein format | Scientific Literature | ||
| 14. | ALA4616960 | B | Inhibition of Escherichia coli beta-glucuronidase | Escherichia coli | 12 | single protein format | Scientific Literature | ||
| 15. | ALA4616980 | B | Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate | Escherichia coli | 3 | single protein format | Scientific Literature | ||
| 16. | ALA4616988 | B | Inhibition of Escherichia coli beta-glucuronidase at 1 mM relative to control | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4829624 | B | Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay | Escherichia coli | 26 | single protein format | Scientific Literature | ||
| 18. | ALA4829625 | B | Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control | Escherichia coli | 21 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!