# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3222525 | B | Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assay relative to 1alpha,25(OH)2D3 | Danio rerio | 2 | ALA3217641 | cell-based format | Scientific Literature | |
2. | ALA3222526 | B | Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assay | Danio rerio | 4 | ALA3217641 | cell-based format | Scientific Literature | |
3. | ALA3222527 | B | Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assay relative to parental gemini | Danio rerio | 2 | ALA3217641 | cell-based format | Scientific Literature | |
4. | ALA3222534 | B | Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assay | Danio rerio | 3 | ALA3217641 | single protein format | Scientific Literature | |
5. | ALA3294717 | B | Binding affinity to N-terminal His-tagged zebrafish VDR LBD (154 to 456) at 10 to 20-fold molar excess by ESI-MS analysis | Danio rerio | 1 | ALA3286103 | single protein format | Scientific Literature | |
6. | ALA4021079 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene at 100 nM after 18 hrs by dual-luciferase transcriptional reporter gene assay | Danio rerio | 1 | ALA4020715 | cell-based format | Scientific Literature | |
7. | ALA4021080 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene at 0.1 nM after 18 hrs by dual-luciferase transcriptional reporter gene assay | Danio rerio | 1 | ALA4020715 | cell-based format | Scientific Literature | |
8. | ALA4021081 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene after 18 hrs by dual-luciferase transcriptional reporter gene assay | Danio rerio | 4 | ALA4020715 | cell-based format | Scientific Literature | |
9. | ALA4021082 | B | Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene at 1000 nM after 18 hrs by dual-luciferase transcriptional reporter gene assay relative to control | Danio rerio | 4 | ALA4020715 | cell-based format | Scientific Literature | |
10. | ALA4622266 | B | Binding affinity to zebrafish VDR LBD assessed as stabilization of structural elements forming LBP at 10 fold excess compound concentration by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
11. | ALA4622267 | B | Binding affinity to H12 region of zebrafish VDR LBD assessed as stabilization of structural elements forming LBP at 10 fold excess compound concentration by HDX-MS analysis | Danio rerio | 2 | ALA4619805 | single protein format | Scientific Literature | |
12. | ALA4622268 | B | Binding affinity to H10 region (416 to 426 residues) of zebrafish VDR LBD assessed as stabilization of structural elements at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 3 and 10 mins by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
13. | ALA4622269 | B | Binding affinity to H12 region (440 to 445 residues) of zebrafish VDR LBD assessed as stabilization of structural elements by measuring increase in protection at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 1 mins by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
14. | ALA4622270 | B | Binding affinity to H3 and H7 region of zebrafish VDR LBD assessed as stabilization of structural elements by measuring increase in protection at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 1 mins by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
15. | ALA4622271 | B | Binding affinity to H3 region (253 to 267 residues) of zebrafish VDR LBD assessed as stabilization of structural elements by measuring increase in protection at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 1 mins by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
16. | ALA4622272 | B | Binding affinity to H6 to H7 region (322 to 344 residues) of zebrafish VDR LBD assessed as stabilization of structural elements by measuring increase in protection at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 1 mins by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
17. | ALA4622273 | B | Binding affinity to H10 to H11 region (416 to 437 residues) of zebrafish VDR LBD assessed as stabilization of structural elements by measuring increase in protection at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 1 mins by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
18. | ALA4622274 | B | Binding affinity to H1 region of zebrafish VDR LBD assessed as stabilization of structural elements forming LBP at 10 fold excess compound concentration by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
19. | ALA4622275 | B | Binding affinity to H2 region of zebrafish VDR LBD assessed as stabilization of structural elements forming LBP at 10 fold excess compound concentration by HDX-MS analysis | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature | |
20. | ALA4622276 | B | Binding affinity to H5 region (290 to 297 residues) of zebrafish VDR LBD assessed as stabilization of structural elements by measuring increase in protection at 10 fold excess compound concentration in presence of SRC1 NR2 coactivator peptide measured at 1 mins by HDX-MS analysis relative to 1,25D3 | Danio rerio | 1 | ALA4619805 | single protein format | Scientific Literature |