| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3266156 | B | Displacement of [3H]-7-alpha,25-OHC from recombinant human EBI2 receptor expressed in CHO cells after 10 mins by scintillation counting analysis | Homo sapiens | 1 | ALA3259772 | cell-based format | Scientific Literature | |
| 2. | ALA3266157 | F | Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay | Homo sapiens | 22 | ALA3259772 | cell-based format | Scientific Literature | |
| 3. | ALA3268995 | F | Competitive antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 7-alpha,25-OHC-induced [35S]GTPgammaS binding after 1 hr by schild plot analysis | Homo sapiens | 1 | ALA3259772 | cell-based format | Scientific Literature | |
| 4. | ALA3268996 | F | Inverse agonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding after 1 hr by scintillation counting analysis | Homo sapiens | 1 | ALA3259772 | cell-based format | Scientific Literature | |
| 5. | ALA3268997 | F | Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.33 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis | Homo sapiens | 1 | ALA3259772 | cell-based format | Scientific Literature | |
| 6. | ALA3268998 | F | Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of 0.1 nM oxysterol-induced [35S]GTPgammaS binding after 1 hr by scintillation counting analysis | Homo sapiens | 1 | ALA3259772 | cell-based format | Scientific Literature | |
| 7. | ALA3268999 | F | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced calcium release measured for 3 mins by FLIPR assay | Homo sapiens | 2 | ALA3259772 | cell-based format | Scientific Literature | |
| 8. | ALA3269346 | B | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of 7-alpha,25-OHC-induced cell migration after 3 hrs by flow cytometric analysis | Homo sapiens | 2 | ALA3259772 | cell-based format | Scientific Literature | |
| 9. | ALA3269347 | B | Antagonist activity at EBI2 receptor in human U937 cells assessed as inhibition of oxysterol-induced cell migration after 3 hrs by flow cytometric analysis | Homo sapiens | 1 | ALA3259772 | cell-based format | Scientific Literature | |
| 10. | ALA3561984 | F | PubChem BioAssay. Dose-response confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) | Homo sapiens | 2 | ALA1201862 | assay format | PubChem BioAssays | |
| 11. | ALA3561999 | F | PubChem BioAssay. SAR confirmation of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assa. (Class of assay: confirmatory) | Homo sapiens | 73 | ALA1201862 | assay format | PubChem BioAssays | |
| 12. | ALA3562080 | F | PubChem BioAssay. Dose-response characterization of small molecule antagonists of the EBI2 receptor via a chemotaxis assay. (Class of assay: confirmatory) | Homo sapiens | 1 | ALA1201862 | assay format | PubChem BioAssays | |
| 13. | ALA4406553 | B | Antagonist activity at human Gi/o-coupled EBI2 expressed in CHOK1 cells assessed as inhibition of 7alpha,25-ihydroxycholesterol-induced beta-arrestin recruitment at 10 uM measured after 120 mins by beta-galactosidase based PathHunter assay relative to control | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
| 14. | ALA4718936 | F | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis | Homo sapiens | 3 | ALA4715765 | cell membrane format | Scientific Literature | |
| 15. | ALA4718939 | F | Agonist activity at Go2-q-coupled human EBI2 expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding at 1 uM preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis relative to control | Homo sapiens | 3 | ALA4715765 | cell membrane format | Scientific Literature | |
| 16. | ALA4718952 | F | Agonist activity at Go2-q-coupled EBI2 (unknown origin) expressed in COS7 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 20 mins followed by [35S]GTPgammaS addition and measured after 1 hr by scintillation counting analysis | Homo sapiens | 4 | ALA4715765 | cell membrane format | Scientific Literature | |
| 17. | ALA4883436 | B | PRESTO-Tango GPCRome screening (GPR183) | 1 | ALA4507309 | single protein format | Donated Chemical Probes - SGC Frankfurt |
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