| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3598537 | Binding | Inhibition of mouse 15-LOX-1 using arachidonic acid as substrate | Mus musculus | 1 | ALA3596137 | single protein format | Scientific Literature | |
| 2. | ALA3766392 | Binding | Inhibition of glutamate-induced 12/15-LOX-dependent cell death in mouse HT22 cells assessed as increase in cell survival at 5 uM by LDH release assay | Mus musculus | 14 | ALA3763110 | cell-based format | Scientific Literature | |
| 3. | ALA1817034 | Binding | Inhibition of mouse N-terminally His6-tagged 15-lipoxygenase expressed in SF9 insect cells assessed as 15-HPETE formation using arachidonic acid by UV-vis spectrophotometer analysis | Mus musculus | 1 | ALA1811753 | cell-based format | Scientific Literature | |
| 4. | ALA3269363 | Binding | Inhibition of 12/15-lipoxygenase in mouse HT22 cells assessed as protection against glutamate-induced cell death after 24 hrs by LDH release assay | Mus musculus | 1 | ALA3259653 | cell-based format | Scientific Literature | |
| 5. | ALA3269364 | Binding | Inhibition of 12/15-lipoxygenase in mouse HT22 cells assessed as reduction of 12-HETE production at 10 uM after 24 hrs by HPLC/MS analysis | Mus musculus | 1 | ALA3259653 | cell-based format | Scientific Literature | |
| 6. | ALA3269365 | Binding | Inhibition of 12/15-lipoxygenase in mouse HT22 cells assessed as protection against glutamate-induced cell death at 5 uM after 24 hrs by LDH release assay | Mus musculus | 3 | ALA3259653 | cell-based format | Scientific Literature | |
| 7. | ALA3864959 | Binding | Inhibition of 15-LOX-mediated lipid oxidation in 10% C57BL/6J mouse plasma | Mus musculus | 2 | ALA3864156 | cell-free format | Scientific Literature | |
| 8. | ALA3864960 | Binding | Inhibition of 15-LOX-mediated lipid oxidation in 10% C57BL/6J mouse plasma at 30 uM | Mus musculus | 4 | ALA3864156 | cell-free format | Scientific Literature | |
| 9. | ALA3871364 | Binding | Inhibition of 15-LOX-1 in C57bl/6 mouse precision-cut lung slices assessed as reduction in LPS-stimulated IL-6 mRNA expression level at 50 uM incubated for 20 hrs followed by LPS stimulation for 4 hrs in presence of linoleic acid by RT-qPCR analysis | Mus musculus | 1 | ALA3871264 | assay format | Scientific Literature | |
| 10. | ALA3871365 | Binding | Inhibition of 15-LOX-1 in C57bl/6 mouse precision-cut lung slices assessed as reduction in LPS-stimulated IL-1beta mRNA expression level at 50 uM incubated for 20 hrs followed by LPS stimulation for 4 hrs in presence of linoleic acid by RT-qPCR analysis | Mus musculus | 1 | ALA3871264 | assay format | Scientific Literature | |
| 11. | ALA3871366 | Binding | Inhibition of 15-LOX-1 in C57bl/6 mouse precision-cut lung slices assessed as reduction in LPS-stimulated IL-8 mRNA expression level at 50 uM incubated for 20 hrs followed by LPS stimulation for 4 hrs in presence of linoleic acid by RT-qPCR analysis | Mus musculus | 1 | ALA3871264 | assay format | Scientific Literature | |
| 12. | ALA3871367 | Binding | Inhibition of 15-LOX-1 in C57bl/6 mouse precision-cut lung slices assessed as reduction in LPS-stimulated IL-12b mRNA expression level at 50 uM incubated for 20 hrs followed by LPS stimulation for 4 hrs in presence of linoleic acid by RT-qPCR analysis | Mus musculus | 1 | ALA3871264 | assay format | Scientific Literature | |
| 13. | ALA3871368 | Binding | Inhibition of 15-LOX-1 in C57bl/6 mouse precision-cut lung slices assessed as reduction in LPS-stimulated TNFalpha mRNA expression level at 50 uM incubated for 20 hrs followed by LPS stimulation for 4 hrs in presence of linoleic acid by RT-qPCR analysis | Mus musculus | 1 | ALA3871264 | assay format | Scientific Literature | |
| 14. | ALA3871369 | Binding | Inhibition of 15-LOX-1 in C57bl/6 mouse precision-cut lung slices assessed as reduction in LPS-stimulated iNOS mRNA expression level at 50 uM incubated for 20 hrs followed by LPS stimulation for 4 hrs in presence of linoleic acid by RT-qPCR analysis | Mus musculus | 1 | ALA3871264 | assay format | Scientific Literature | |
| 15. | ALA3871370 | Binding | Inhibition of 15-LOX-1 in mouse HT22 cells assessed as inhibition of glutamate-induced lipid peroxidation at 10 uM incubated for 6 to 7 hrs by BODIPY 581/591 C11 staining based FACS analysis | Mus musculus | 1 | ALA3871264 | cell-based format | Scientific Literature | |
| 16. | ALA3871371 | Binding | Inhibition of 15-LOX-1 in mouse HT22 cells assessed as inhibition of glutamate-induced lipid peroxidation at 1 uM incubated for 14 to 16 hrs by BODIPY 581/591 C11 staining based FACS analysis | Mus musculus | 1 | ALA3871264 | cell-based format | Scientific Literature | |
| 17. | ALA3871372 | Binding | Inhibition of 15-LOX-1 in mouse HT22 cells assessed as inhibition of glutamate-induced superoxide production in mitochondria at 10 uM incubated for 14 to 16 hrs by mitoSOX staining based FACS analysis | Mus musculus | 1 | ALA3871264 | mitochondrion format | Scientific Literature | |
| 18. | ALA3871373 | Binding | Inhibition of 15-LOX-1 in mouse HT22 cells assessed as protection against glutamate-induced cell death by measuring increase in cell viability up to 20 uM cotreated with glutamate for 14 to 16 hrs by MTT assay | Mus musculus | 1 | ALA3871264 | cell-based format | Scientific Literature | |
| 19. | ALA3871374 | Binding | Inhibition of 15-LOX-1 in mouse HT22 cells assessed as protection against glutamate-induced cell impedance at 5 to 10 uM cotreated with glutamate measured for 16 to 20 hrs by real time cell viability assay | Mus musculus | 1 | ALA3871264 | cell-based format | Scientific Literature | |
| 20. | ALA3871375 | Binding | Inhibition of 15-LOX-1 in mouse HT22 cells assessed as protection against glutamate-induced cell death by measuring increase in cell viability at 1 uM cotreated with glutamate measured for 16 to 20 hrs by MTT assay | Mus musculus | 1 | ALA3871264 | cell-based format | Scientific Literature |
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