# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3270982 | B | Inhibition of BTK-mediated CD86 surface expression in mouse splenic B cells after 18 hrs by antibody-based FACS analysis | Mus musculus | 1 | ALA3259754 | cell-based format | Scientific Literature | |
2. | ALA3406075 | B | Inhibition of BTK-mediated CD86 surface expression in Balb/c mouse splenocytes preincubated for 60 mins before F(ab')2 anti-mouse IgM measured after 24 hrs by flow cytometry | Mus musculus | 20 | ALA3400008 | cell-based format | Scientific Literature | |
3. | ALA3611665 | B | Inhibition of RANKL-mediated Btk phosphorylation in mouse BMMC at 100 uM after 1 hr by Western blot analysis | Mus musculus | 1 | ALA3608225 | single protein format | Scientific Literature | |
4. | ALA3748502 | B | Inhibition of BTK in Balb/c mouse B cells assessed as inhibition of anti-IgM-stimulated CD86 expression by flow cytometry | Mus musculus | 10 | ALA3745631 | cell-based format | Scientific Literature | |
5. | ALA3858936 | B | Inhibition of BTK in mouse whole blood assessed as suppression of BCR/anti-IgM/IgG-stimulated CD69 surface expression after 18 hrs with agitation by FITC-staining based FACS analysis | Mus musculus | 2 | ALA3856250 | tissue-based format | Scientific Literature | |
6. | ALA4036700 | B | Inhibition of BTK in goat F(ab')2anti-mouse IgM-stimulated Balb/c mouse splenocyte B cells assessed as suppression of BCR-mediated CD86 induction preincubated for 60 mins followed by cell stimulation measured after 24 hrs by 7AAD staining-based FACS analysis | Mus musculus | 19 | ALA4033752 | assay format | Scientific Literature | |
7. | ALA4178245 | B | Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins followed by antibody challenge after 18 to 24 hrs by flow cytometry | Mus musculus | 17 | ALA4177534 | single protein format | Scientific Literature | |
8. | ALA4178259 | B | Inhibition of mouse BTK assessed as decrease in anti-mouse IgD antibody stimulated BCR mediated CD69 upregulation in whole blood preincubated for 1 hr followed by antibody challenge after 4 hrs by flow cytometry | Mus musculus | 2 | ALA4177534 | single protein format | Scientific Literature | |
9. | ALA4178260 | B | Inhibition of mouse BTK assessed as decrease in anti-CD3epsilon antibody stimulated TCR mediated CD69 upregulation in whole blood preincubated for 1 hr followed by antibody challenge after 4 hrs by flow cytometry | Mus musculus | 2 | ALA4177534 | single protein format | Scientific Literature | |
10. | ALA4429407 | B | Inhibition of BTK in mouse whole blood assessed as suppression of BCR/anti-IgM stimulated CD69 surface expression on B cells after 18 hrs by FACS analysis | Mus musculus | 1 | ALA4428066 | tissue-based format | Scientific Literature | |
11. | ALA4616838 | F | In-vivo inhibition of BTK in single po dosed BALB/c mouse | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
12. | ALA4616839 | F | In-vivo inhibition of BTK in BALB/c mouse at 0.5 mg/kg, po single dose after 4 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
13. | ALA4616840 | F | In-vivo inhibition of BTK in BALB/c mouse at 0.5 mg/kg, po single dose after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
14. | ALA4616841 | F | In-vivo inhibition of BTK in BALB/c mouse at 0.5 to 2.5 mg/kg, po single dose after 48 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
15. | ALA4616848 | F | In-vivo inhibition of BTK in DBA1/J mouse model of collagen-induced arthritis at 0.1 mg/kg, po qd after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
16. | ALA4616849 | F | In-vivo inhibition of BTK in DBA1/J mouse model of collagen-induced arthritis at 0.5 mg/kg, po qd after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
17. | ALA4616850 | F | In-vivo inhibition of BTK in DBA1/J mouse model of collagen-induced arthritis at 2.5 mg/kg, po qd after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
18. | ALA4616868 | F | In-vivo inhibition of BTK in NZB/WF1 mouse model of lupus prone at 0.2 mg/kg, po qd administered via gavage measured after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
19. | ALA4616869 | F | In-vivo inhibition of BTK in NZB/WF1 mouse model of lupus prone at 0.5 mg/kg, po qd administered via gavage measured after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature | |
20. | ALA4616870 | F | In-vivo inhibition of BTK in NZB/WF1 mouse model of lupus prone at 1.5 mg/kg, po qd administered via gavage measured after 24 hrs relative to control | Mus musculus | 1 | ALA4616583 | organism-based format | Scientific Literature |