| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5251906 | F | In vivo protein occupancy at BTK in ICR mouse splenocyte at 15 mg/kg, po administered as single dose and measured after 4 hrs by ELISA analysis relative to control | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 2. | ALA5251964 | F | In vivo protein occupancy at BTK in ICR mouse spleen at 25 mg/kg, po administered as single dose and measured upto 24 hrs by ELISA analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5251965 | F | In vivo protein occupancy at BTK in ICR mouse PBMC at 25 mg/kg, po administered as single dose and measured upto 24 hrs by ELISA analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA5251966 | F | In vivo protein occupancy at BTK in ICR mouse spleen at 25 mg/kg, po administered as single dose and measured at 0.5 hrs hrs by ELISA analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA5251967 | F | In vivo protein occupancy at BTK in ICR mouse PBMC at 25 mg/kg, po administered as single dose and measured at 0.5 hrs hrs by ELISA analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA5251968 | F | In vivo protein occupancy at BTK in ICR mouse spleen assessed as unoccupied BTK level at 25 mg/kg, po administered as single dose and measured 24 hrs postdose by ELISA analysis relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5251969 | F | In vivo protein occupancy at BTK in ICR mouse PBMC assessed as unoccupied BTK level at 25 mg/kg, po administered as single dose and measured 24 hrs postdose by ELISA analysis relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5251970 | F | Invivo protein occupancy at BTK in po dosed ICR mouse spleen measured after 4 hrs by ELISA analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5251971 | F | Invivo protein occupancy at BTK in po dosed ICR mouse PBMC measured after 4 hrs by ELISA analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3270982 | B | Inhibition of BTK-mediated CD86 surface expression in mouse splenic B cells after 18 hrs by antibody-based FACS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3406075 | B | Inhibition of BTK-mediated CD86 surface expression in Balb/c mouse splenocytes preincubated for 60 mins before F(ab')2 anti-mouse IgM measured after 24 hrs by flow cytometry | Mus musculus | 20 | cell-based format | Scientific Literature | ||
| 12. | ALA3611665 | B | Inhibition of RANKL-mediated Btk phosphorylation in mouse BMMC at 100 uM after 1 hr by Western blot analysis | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3748502 | B | Inhibition of BTK in Balb/c mouse B cells assessed as inhibition of anti-IgM-stimulated CD86 expression by flow cytometry | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 14. | ALA3858936 | B | Inhibition of BTK in mouse whole blood assessed as suppression of BCR/anti-IgM/IgG-stimulated CD69 surface expression after 18 hrs with agitation by FITC-staining based FACS analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 15. | ALA4036700 | B | Inhibition of BTK in goat F(ab')2anti-mouse IgM-stimulated Balb/c mouse splenocyte B cells assessed as suppression of BCR-mediated CD86 induction preincubated for 60 mins followed by cell stimulation measured after 24 hrs by 7AAD staining-based FACS analysis | Mus musculus | 19 | assay format | Scientific Literature | ||
| 16. | ALA4178245 | B | Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins followed by antibody challenge after 18 to 24 hrs by flow cytometry | Mus musculus | 17 | single protein format | Scientific Literature | ||
| 17. | ALA4178259 | B | Inhibition of mouse BTK assessed as decrease in anti-mouse IgD antibody stimulated BCR mediated CD69 upregulation in whole blood preincubated for 1 hr followed by antibody challenge after 4 hrs by flow cytometry | Mus musculus | 2 | single protein format | Scientific Literature | ||
| 18. | ALA4178260 | B | Inhibition of mouse BTK assessed as decrease in anti-CD3epsilon antibody stimulated TCR mediated CD69 upregulation in whole blood preincubated for 1 hr followed by antibody challenge after 4 hrs by flow cytometry | Mus musculus | 2 | single protein format | Scientific Literature | ||
| 19. | ALA4429407 | B | Inhibition of BTK in mouse whole blood assessed as suppression of BCR/anti-IgM stimulated CD69 surface expression on B cells after 18 hrs by FACS analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 20. | ALA4616838 | F | In-vivo inhibition of BTK in single po dosed BALB/c mouse | Mus musculus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!