| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1044640 | B | Inhibition of kallikrein 8 assessed as residual activity at 10 uM after 10 to 15 mins by fluorescence assay relative to control | 1 | single protein format | Scientific Literature | |||
| 2. | ALA1039262 | B | Inhibition of kallikrein 8 after 10 to 15 mins by fluorescence assay | 1 | single protein format | Scientific Literature | |||
| 3. | ALA2339962 | B | Inhibition of Kallikrein-8 (unknown origin) using VPR-AMC substrate incubated for 15 mins prior to substrate addition measured for 2 hrs | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA2339093 | B | Inhibition of Kallikrein-8 (unknown origin) using VPR-AMC substrate assessed as residual activity at 10 uM incubated for 15 mins prior to substrate addition measured for 2 hrs | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA3413942 | B | Inhibition of human KLK8 using Boc-Val-Pro-Arg-AMC as substrate at 50 uM after 15 mins by fluorescence assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 6. | ALA3772679 | B | Inhibition of human recombinant KLK8 expressed in Escherichia coli using Bachem I-1120 as substrate preincubated for 15 mins followed by substrate addition by microplate reader analysis | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 7. | ALA3772690 | B | Reversible inhibition of human recombinant KLK8 expressed in Escherichia coli using Boc-Val-Pro-Arg-AMC as fluorogenic substrate at 100 times IC50 preincubated for 15 mins followed by 100 fold dilution measured for 1 hr | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 8. | ALA3772691 | B | Irreversible inhibition of human recombinant KLK8 expressed in Escherichia coli using Boc-Val-Pro-Arg-AMC as fluorogenic substrate at 100 times IC50 preincubated for 15 mins followed by 100 fold dilution measured for 1 hr | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4201845 | B | Inhibition of KLK8 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA4388474 | A | Inhibition of recombinant C-terminal 10-His tagged human KLK8 (Gln29 to Gly260 residues) expressed in mouse NS0 cells using BOC-VPR-AMC as substrate after 40 mins by fluorescence intensity assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4400465 | B | Inhibition of recombinant human C-terminal 10-His-tagged KLK8 (Gln29 to Gly260 residues) expressed in mouse NS0 cells using BOC-VPR-AMC as substrate incubated for 40 mins by FLINT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 12. | ALA4831730 | B | Inhibition of KLK8 (unknown origin) assessed as inhibition of release of AMC fluorescent product using H-VPR-AMC as substrate at 10 uM incubated for 30 mins by microplate reader relative to control | Homo sapiens | 7 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!