| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3300134 | Binding | Enhancement of GLUT4 translocation in rat L6 cells expressing pIRAP-mOrange cDNAs at 10 uM after 10 mins by fluorescence assay relative to control | Rattus norvegicus | 13 | ALA3297643 | cell-based format | Scientific Literature | |
| 2. | ALA3294657 | Binding | Induction of GLUT4 translocation to cell surface in rat L6-GLUT4myc cells at 10 uM treated for 16 hrs followed by incubation for 3 hrs in serum free medium and insulin stimulation for 20 mins | Rattus norvegicus | 4 | ALA3286380 | cell-based format | Scientific Literature | |
| 3. | ALA3367592 | Binding | Stimulation of rat GLUT4-mediated glucose uptake in rat L6 cells expressing myc-tagged GLUT4 at 10 uM incubated for 16 hrs by scintillation counting based 2-[3H]DG uptake assay | Rattus norvegicus | 22 | ALA3351811 | cell-based format | Scientific Literature | |
| 4. | ALA3367594 | Binding | Stimulation of rat GLUT4-mediated glucose uptake in rat L6 cells expressing myc-tagged GLUT4 incubated for 16 hrs by scintillation counting based 2-[3H]DG uptake assay | Rattus norvegicus | 5 | ALA3351811 | cell-based format | Scientific Literature | |
| 5. | ALA3367827 | Binding | Induction of rat GLUT4 translocation in rat L6 cells expressing myc-tagged GLUT4 incubated for 3 hrs by antibody-coupled colourimetric assay | Rattus norvegicus | 7 | ALA3351811 | cell-based format | Scientific Literature | |
| 6. | ALA3367828 | Binding | Stimulation of rat GLUT4-mediated glucose uptake in rat L6 cells expressing myc-tagged GLUT4 at 10 uM incubated for 16 hrs in presence of 1 uM PI3K inhibitor wortmannin by scintillation counting based 2-[3H]DG uptake assay | Rattus norvegicus | 7 | ALA3351811 | cell-based format | Scientific Literature | |
| 7. | ALA3411617 | Binding | Induction of GLUT4 translocation in rat L6 cells assessed as increase in 2-deoxyglucose uptake relative to control | Rattus norvegicus | 2 | ALA3407496 | cell-based format | Scientific Literature | |
| 8. | ALA3992730 | Binding | Competitive inhibition of GLUT4 in Wistar rat adipocytes assessed as reduction in insulin-stimulated 3-O-[3H]methyl-D-glucose uptake measured for 30 secs by Lineweaver-Burk plot analysis | Rattus norvegicus | 2 | ALA3992488 | cell-based format | Scientific Literature | |
| 9. | ALA3999837 | Binding | Enhancement of GLUT4 translocation at plasma membrane of rat L6 cells expressing pIRAP-mOrange at 10 uM after 30 mins by fluorescence assay relative to control | Rattus norvegicus | 13 | ALA3997838 | assay format | Scientific Literature | |
| 10. | ALA3999838 | Binding | Enhancement of GLUT4 translocation at plasma membrane of rat L6 cells expressing pIRAP-mOrange after 30 mins by laser-scanning confocal microscopic method | Rattus norvegicus | 1 | ALA3997838 | assay format | Scientific Literature | |
| 11. | ALA3999839 | Binding | Enhancement of GLUT4 translocation at plasma membrane of rat L6 cells expressing pIRAP-mOrange at >10 uM after 30 mins by laser-scanning confocal microscopic method relative to control | Rattus norvegicus | 1 | ALA3997838 | assay format | Scientific Literature | |
| 12. | ALA4132891 | Binding | Antagonist activity at GLUT4 in rat adipocytes assessed as reduction in insulin-stimulated [3H]2-deoxyglucose uptake preincubated for 1 min followed by [3H]2-deoxyglucose addition measured after 1 min by liquid scintillation counting analysis | Rattus norvegicus | 1 | ALA4130400 | cell-based format | Scientific Literature | |
| 13. | ALA4132892 | Binding | Antagonist activity at rat C-terminal 6His/Myc-tagged GLUT4 assessed as reduction in 2-[3H]deoxyglucose uptake measured after 6 mins | Rattus norvegicus | 1 | ALA4130400 | single protein format | Scientific Literature | |
| 14. | ALA4132906 | Binding | Displacement of ATB-BMPA from rat C-terminal 6His/Myc-tagged GLUT4 expressed in HEK293 cell low density microsome assessed as ATB-BMPA binding level at 20 uM preincubated for 10 mins followed by ATB-BMPA addition measured after 10 mins relative to control | Rattus norvegicus | 1 | ALA4130400 | cell-based format | Scientific Literature | |
| 15. | ALA4132908 | Binding | Displacement of ATB-BMPA from rat C-terminal 6His/Myc-tagged GLUT4 expressed in HEK293 cell low density microsome at 20 uM preincubated for 10 mins followed by ATB-BMPA addition measured after 10 mins | Rattus norvegicus | 1 | ALA4130400 | cell-based format | Scientific Literature | |
| 16. | ALA4342209 | Binding | Induction of GLUT4 translocation in rat L6-GLUT4myc differentiated myotube cells at 30 uM after 20 mins by chemiluminescent method relative to 30 uM 2-(4-(4-phenylphthalazin-1-ylamino)phenyl)acetamide | Rattus norvegicus | 15 | ALA4340562 | assay format | Scientific Literature | |
| 17. | ALA4342210 | Binding | Induction of GLUT4 translocation in rat L6-GLUT4myc differentiated myotube cells at 3 uM after 20 mins by chemiluminescent method relative to 30 uM 2-(4-(4-(2-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-ylamino)phenyl)acetamide | Rattus norvegicus | 25 | ALA4340562 | assay format | Scientific Literature | |
| 18. | ALA4342211 | Binding | Induction of GLUT4 translocation in rat L6-GLUT4myc differentiated myotube cells at 3 uM after 20 mins by chemiluminescent method relative to 2-(4-(4-(2-methoxyphenyl)phthalazin-1-ylamino)phenyl)acetamide | Rattus norvegicus | 1 | ALA4340562 | assay format | Scientific Literature | |
| 19. | ALA4342212 | Binding | Induction of GLUT4 translocation in rat L6-GLUT4myc differentiated myotube cells after 20 mins by chemiluminescent method | Rattus norvegicus | 11 | ALA4340562 | assay format | Scientific Literature | |
| 20. | ALA4342215 | Binding | Potency index, ratio of EC50 for 2-(4-(4-(2-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-ylamino)phenyl)acetamide EC50 to EC50 for test compound for GLUT4 translocation activity in L6-GLUT4myc differentiated myotube cells | Rattus norvegicus | 1 | ALA4340562 | assay format | Scientific Literature |
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