| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2329040 | B | Inhibition of JAK1/JAK2/TYK2 in human PBMC expressing CD14 assessed as inhibition of IL-6-stimulated STAT3 phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 2. | ALA2329042 | B | Inhibition of JAK1/JAK2/TYK2 in human PBMC expressing CD3 assessed as inhibition of IL-6-stimulated STAT3 phosphorylation after 30 mins by flow cytometric analysis | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 3. | ALA3299205 | B | Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by IL-6 addition measured after 15 mins by FACS analysis | Homo sapiens | 5 | protein complex format | Scientific Literature | ||
| 4. | ALA3766667 | B | Inhibition of JAK1/JAK2/TYK2 in human PBMC assessed as reduction in IL-6-induced STAT1 phosphorylation preincubated for 5 mins followed by IL-6 stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 5. | ALA4023008 | B | Inhibition of JAK1/JAK2/TYK2 in CD14+ human whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed by IL-6 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 6. | ALA4124201 | B | Inhibition of JAK1/JAK2/TYK2 in human CD4 positive T cells assessed as inhibition of IL6-stimulated STAT3 phosphorylation at >300 nM preincubated for 1 hr followed by IL-6 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4124204 | B | Inhibition of JAK1/JAK2/TYK2 in human CD4 positive T cells assessed as inhibition of IL6-stimulated STAT3 phosphorylation up to 1000 nM preincubated for 1 hr followed by IL-6 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4124209 | B | Inhibition of JAK1/JAK2/TYK2 in human CD4 positive T cells assessed as inhibition of IL6-stimulated STAT3 phosphorylation at 1000 nM preincubated for 1 hr followed by IL-6 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4675846 | B | Inhibition of TYK2/JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 addition and measured measured after 15 mins by FACS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4675847 | B | Inhibition of TYK2/JAK1/JAK2 signaling pathway in human whole blood spiked with CD3 +ve cells assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed by IL-6 addition and measured measured after 15 mins by immunostaining based FACS assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4675848 | B | Inhibition of TYK2/JAK1/JAK2 signaling pathway in human whole blood spiked with CD3 +ve cells assessed as reduction in IL-6 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-6 addition and measured measured after 15 mins by immunostaining based FACS assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4825802 | B | Inhibition of JAK1/JAK2/TYK2 signaling pathway in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at 100 to 5000 nM preincubated for 60 mins followed by IL-6 addition and measured measured after 15 mins by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5041957 | B | Inhibition of JAK1/JAK2/TYK2 in human TF-1 cells assessed as inhibition of rhIL-6-stimulated STAT3 phosphorylation at 5000 nM measured after 1.5 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5047435 | B | Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 15. | ALA5154543 | B | Inhibition of JAK1/JAK2/TYK2 signalling in human whole blood assessed as inhibition of IL-6 stimulated STAT1 phosphorylation in CD4+ lymphocytes preincubated for 1 hr followed by IL-6 stimulation and incubated for 20 mins by flow cytometry analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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