| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5252492 | B | Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by IFN alpha stimulation for 15 mins by flow cytometry method | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA3299207 | B | Inhibition of JAK1/TYK2 in human whole blood assessed as inhibition of IFN-alpha-induced STAT-3 phosphorylation preincubated for 45 mins followed by IFN-alpha addition measured after 15 mins by FACS analysis | Homo sapiens | 5 | protein complex format | Scientific Literature | ||
| 3. | ALA3382728 | B | Inhibition of JAK1/TYK2 in IFN-alphaB2-induced human U2OS cells assessed as pSTAT1 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3766666 | B | Inhibition of TYK2/JAK1 in human PBMC assessed as reduction in IFNalpha-induced STAT1 phosphorylation preincubated for 5 mins followed by IFNalpha stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 5. | ALA4003464 | B | Inhibition of JAK1/TYK2 in human whole blood lymphocytes assessed as inhibition of IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFNalpha addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4003465 | B | Inhibition of JAK2/TYK2 in human whole blood lymphocytes assessed as inhibition of IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL23 addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4003483 | B | Inhibition of JAK1/TYK2 in human whole blood lymphocytes assessed as inhibition of IFNalpha induced STAT3 phosphorylation by measuring free compound concentration required for the effect preincubated for 45 mins followed by IFNalpha addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4003484 | B | Inhibition of JAK2/TYK2 in human whole blood lymphocytes assessed as inhibition of IL-23 induced STAT3 phosphorylation by measuring free compound concentration required for the effect preincubated for 45 mins followed by IL23 addition and measured after 20 mins by flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4022972 | B | Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFNalpha addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 43 | protein complex format | Scientific Literature | ||
| 10. | ALA4023009 | B | Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IL-10 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-10 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 11. | ALA4047237 | B | Inhibition of JAK1/TYK2 in human PBMC derived T cell assessed as reduction in IFNa2a-induced STAT3 phosphorylation after 30 mins by ELISA | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 12. | ALA4124205 | B | Inhibition of JAK1/TYK2 in human CD4 positive T cells assessed as inhibition of IFNalpha-stimulated STAT1 phosphorylation at Tyr-695 residue up to 1000 nM preincubated for 1 hr followed by IFNalpha stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4124208 | B | Inhibition of JAK1/TYK2 in human CD4 positive T cells assessed as inhibition of IFNalpha-stimulated STAT1 phosphorylation at Tyr-695 residue at 1000 nM preincubated for 1 hr followed by IFNalpha stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4265578 | B | Inhibition of JAK1/TYK2 in human PBMC assessed as reduction in IL10-induced STAT3 phosphorylation preincubated for 75 mins followed by IL10 addition and measured after 15 mins by FACS analysis | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 15. | ALA4332987 | B | Inhibition of JAK1/TYK2 in human PBMC assessed as reduction in IFNalpha-induced STAT1 phosphorylation at 10 uM preincubated for 2 hrs followed by IFNalpha stimulation measured after 30 mins by Western blot | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 16. | ALA4377380 | B | Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 17. | ALA4404830 | B | Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimulation for 30 mins AlphaLISAassay | Homo sapiens | 12 | protein complex format | Scientific Literature | ||
| 18. | ALA4404837 | B | Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IL12 -induced STAT4 phosphorylation pre-incubated for 30 mins before IL12 stimulation for 30 mins AlphaLISAassay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 19. | ALA4411582 | B | Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN-alpha addition and measured measured after 15 mins by FACS assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 20. | ALA4411586 | B | Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-10 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-10 addition and measured measured after 15 mins by FACS assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
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