| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3299206 | B | Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-12-induced STAT-4 phosphorylation preincubated for 45 mins followed by IL-12 addition measured after 15 mins by FACS analysis | Homo sapiens | 5 | protein complex format | Scientific Literature | ||
| 2. | ALA3299208 | B | Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-23-induced STAT-3 phosphorylation preincubated for 45 mins followed by IL-23 addition measured after 15 mins by FACS analysis | Homo sapiens | 5 | protein complex format | Scientific Literature | ||
| 3. | ALA3766658 | B | Inhibition of TYK2/JAK2 in human PBMC assessed as reduction in IL-23-induced STAT4 phosphorylation preincubated for 5 mins followed by IL-23 stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 4. | ALA4023013 | B | Inhibition of JAK2/TYK2 in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubated for 45 mins followed by IL-12 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 5. | ALA4023014 | B | Inhibition of JAK2/TYK2 in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-23 addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 6. | ALA4411590 | B | Inhibition of JAK2/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-23 addition and measured measured after 15 mins by FACS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4414789 | B | Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 25 | assay format | Scientific Literature | ||
| 8. | ALA4620446 | B | Inhibition of TYK2/JAK2 in human whole blood assessed as free fraction of of IL12-induced STAT4 phosphorylation by flow cytometry | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4620447 | B | Inhibition of TYK2/JAK2 in human whole blood assessed as free fraction of of IL23-induced STAT3 phosphorylation by flow cytometry | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4630021 | B | Inhibition of JAK2/Tyk2 in human PBMC assessed as reduction in IL-23-induced Stat3 phosphorylation in CD3+CD4+ cells preincubated for 30 mins followed by IL-23 stimulation and measured after 15 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4675843 | B | Inhibition of JAK2/TYK2 signaling pathway in human whole blood lymphocytes assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-23 addition and measured measured after 15 mins by immunostaining based FACS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4825793 | B | Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation incubated for 60 mins followed by IL-12 addition and measured after 20 mins by fluorescence assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4825794 | B | Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation incubated for 60 mins followed by IL-23 addition and measured after 20 mins by fluorescence assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4825798 | B | Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation by measuring free plasma concentration incubated for 60 mins followed by IL-12 addition and measured after 20 mins by fluorescence assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA4825799 | B | Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation by measuring free plasma concentration incubated for 60 mins followed by IL-23 addition and measured after 20 mins by fluorescence assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA4825803 | B | Inhibition of JAK1/TYK2 signaling pathway in human H9 cells assessed as reduction in IFN-alpha induced STAT1 phosphorylation at 100 to 5000 nM preincubated for 60 mins followed by IFN-alpha addition and measured measured after 15 mins by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5041961 | B | Inhibition of JAK2/TYK2 signalling in human PBMC assessed as inhibition of IL-23 stimulated phosphorylation of STAT3 preincubated for 60 mins followed by IL-23 stimulation for 20 mins by flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5120644 | B | Inhibition of JAK2/TYK2 signaling pathway in human primary T-cells assessed as reduction of IL-12 induced STAT4 phosphorylation | Homo sapiens | 1 | cell-based format | Scientific Literature |
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