| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3269775 | B | Agonist activity at human recombinant TLR2/6 expressed in HEK293 cells at 10 uM by SEAP reporter assay | Homo sapiens | 1 | ALA3259572 | cell-based format | Scientific Literature | |
| 2. | ALA4195482 | B | Antagonist activity at human TLR2/6 expressed in HEK293 cells assessed as decrease in Pam2CSK4-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 3. | ALA4222358 | B | Antagonist activity at human TLR2/6 expressed in HEK-blue cells assessed as inhibition of Pam2CSK4-induced NF-kappaB activation-mediated SEAP production at 25 uM after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
| 4. | ALA4222366 | B | Antagonist activity at human TLR2/6 expressed in HEK-blue cells assessed as inhibition of Pam2CSK4-induced IL-8 mRNA expression at 100 uM preincubated for 1 hr followed by Pam2CSK4 induction measured after 1 hr by qRT-PCR method relative to control | Homo sapiens | 1 | ALA4219143 | cell-based format | Scientific Literature | |
| 5. | ALA4235565 | B | Antagonist activity at FLAG-tagged human TLR2/TLR6 expressed in HEK293 cells co-expressing pGL3-Elam.luc assessed as inhibition of Pam2CSK4-stimulated NF-kappaB activation preincubated for 1 hr followed by Pam2CSK4 stimulation for 5 hrs by luciferase reporter gene assay | Homo sapiens | 2 | ALA4229513 | cell-based format | Scientific Literature | |
| 6. | ALA4346941 | B | Agonist activity at human TLR2/6 expressed in HEK-Blue cells assessed as activation of SEAP at 0.5 uM incubated for 24 hrs by quanti-blue SEAP assay in presence of Anti-hTLR6-IgG | Homo sapiens | 1 | ALA4346656 | cell-based format | Scientific Literature | |
| 7. | ALA4356432 | B | Inhibition of human TLR2/6 expressed in HEK293 cells assessed as reduction in Pam2CSK4-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay | Homo sapiens | 1 | ALA4354819 | cell-based format | Scientific Literature | |
| 8. | ALA4359298 | B | Inhibition of human TLR2/6 expressed in HEK-Blue cells assessed as inhibition of Pam2CSK4-induced NF-kappaB activation at 20 uM measured after 24 hrs by quanti-blue based SEAP reporter gene assay | Homo sapiens | 1 | ALA4354873 | cell-based format | Scientific Literature | |
| 9. | ALA4361585 | B | Antagonist activity at TLR2/6 in human PBMC cells assessed as reduction in FSL-1-induced TNFalpha secretion at 20 to 80 uM after 24 hrs by ELISA | Homo sapiens | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 10. | ALA4361586 | B | Antagonist activity at TLR2/6 in human PBMC cells assessed as reduction in FSL-1-induced IL6 secretion at 20 to 80 uM after 24 hrs by ELISA | Homo sapiens | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 11. | ALA4361618 | B | Antagonist activity at TLR2/6 in human THP1 cells assessed as reduction in FSL-1-induced IL6 secretion at 50 uM after 24 hrs by ELISA | Homo sapiens | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 12. | ALA4399002 | B | Inhibition of PAM2CSK4-induced TLR2/6 activation in human HEK-Blue hTLR2 cells | Homo sapiens | 1 | ALA4396907 | cell-based format | Scientific Literature | |
| 13. | ALA4434015 | B | Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR6-IGG for 2 hrs by ELISA | Homo sapiens | 3 | ALA4433228 | cell-based format | Scientific Literature | |
| 14. | ALA4434016 | B | Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR1-IGA for 2 hrs by ELISA | Homo sapiens | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 15. | ALA5105455 | B | Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay | Homo sapiens | 11 | ALA5104121 | cell-based format | Scientific Literature | |
| 16. | ALA5105456 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-6 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | ALA5104121 | cell-based format | Scientific Literature | |
| 17. | ALA5105457 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-10 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | ALA5104121 | cell-based format | Scientific Literature | |
| 18. | ALA5105458 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | ALA5104121 | cell-based format | Scientific Literature | |
| 19. | ALA5226502 | B | Agonist activity at TLR2/TLR6 (unknown origin) assessed as induction of IL-8 production relative to control | Homo sapiens | 1 | ALA5226282 | protein complex format | Scientific Literature |
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