# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4384518 | B | Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
2. | ALA4384519 | B | Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation at 30 uM preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
3. | ALA4603681 | B | Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4603682 | B | Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level at 50 uM by LANCE Ultra cAMP Detection kit method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4685442 | A | Agonist activity at recombinant human AC8 expressed in HEK293 cells assessed as increase in cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
6. | ALA5161377 | B | Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
7. | ALA5161378 | B | Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
8. | ALA5161381 | B | Inhibition of Ca2+/ CAM stimulated human AC8 expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
9. | ALA5218112 | B | Inhibition of human ADCY8 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis | Homo sapiens | 1 | single protein format | Scientific Literature |