# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3383262 | B | Inhibition of PINK (unknown origin) assessed as remaining enzyme activity at 10 uM by radioactive [33P]-ATP filter binding assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
2. | ALA4050384 | B | Inhibition of human PINK assessed as residual activity at 1 uM in presence of [33P]ATP by filter binding assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
3. | ALA4050840 | B | Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressing wild-type Parkin assessed as Parkin Ser65 phosphorylation at 50 uM after 24 hrs in absence of CCCP by immunoblotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA4050841 | B | Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressing wild-type Parkin assessed as Parkin Ser65 phosphorylation at 50 uM in absence of CCCP by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4050842 | B | Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressed with Parkin S65A mutant assessed as Parkin phosphorylation at 50 uM in absence of CCCP by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4050843 | B | Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressed with wild-type Parkin assessed as Parkin Ser65 phosphorylation at 10 uM by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4884812 | B | PINK1(PIN1PHRE) Takeda global kinase panel | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
8. | ALA4885103 | B | PINK1(PIN1PHRE) Takeda global kinase panel | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
9. | ALA4885390 | B | PINK1(PIN1PHRE) Takeda global kinase panel | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
10. | ALA5051604 | B | Activation of PINK1 in human HeLa cells stably expressing YFP parkin assessed as reduction in dOTC protein accumulation and measured by ornithine carbamoyltransferase (DOTC) assay relative to control | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
11. | ALA5051605 | B | Activation of PINK1 in human HeLa MKYP cells expressing PINK1 treated with FCCP/oilgomycin assessed as increase in pS65 Ub and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA5051606 | B | Activation of PINK1 in human HeLa MKYP PINK1-knock out cells treated with FCCP/oilgomycin assessed as increase in pS65 Ub and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA5051607 | B | Activation of PINK1 in human HeLa MKYP cells expressing PINK1 treated with FCCP/oilgomycin assessed as increase in parkin recruitment and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA5051608 | B | Activation of PINK1 in human HeLa MKYP PINK1-knock out cells treated with FCCP/oilgomycin assessed as increase in parkin recruitment and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA5051611 | B | Activation of PINK1 in human iPSC derived neurons at 3.1 to 6.2 uM assessed as reduction in pS129 alpha-synuclein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA5051612 | B | Activation of PINK1 in human HeLa MKYP PINK1-knock out cells at 3.125 to 6.25 uM assessed as reduction in pS129 alpha-synuclein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data |