# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1115416 | B | Inhibition of PARP in hydrogen peroxide-induced human HeLa cells assessed as inhibition DNA-damage-induced PARylation | Homo sapiens | 30 | ALA1157008 | cell-based format | Scientific Literature | |
2. | ALA1814971 | B | Inhibition of PARP in human SCC25 cells assessed as inhibition of MNNG-induced NAD(H) depletion at 1 mM preincubated for 5 mins before MNNG challenge measured after 30 mins | Homo sapiens | 5 | ALA1811898 | cell-based format | Scientific Literature | |
3. | ALA2330714 | B | Inhibition of PARP1/PARP2 in human SKOV3 cells assessed as reduction in H2O2-induced PARylation incubated for 4 hrs prior to H2O2 treatment | Homo sapiens | 3 | ALA2321760 | cell-based format | Scientific Literature | |
4. | ALA3428886 | B | Inhibition of PARP in human HeLa cells assessed as inhibition of hydrogen peroxide-induced PARylation by cell-based assay | Homo sapiens | 9 | ALA3425485 | cell-based format | Scientific Literature | |
5. | ALA3429594 | B | Inhibition of PARP in human A2780 cells assessed as inhibition of hydrogen peroxide-induced PARylation by cell-based assay | Homo sapiens | 1 | ALA3425485 | cell-based format | Scientific Literature | |
6. | ALA3429595 | B | Inhibition of PARP in BRCA2-deficient human CAPAN-1 cells assessed as inhibition of hydrogen peroxide-induced PARylation by cell-based assay | Homo sapiens | 1 | ALA3425485 | cell-based format | Scientific Literature | |
7. | ALA3429724 | F | Inhibition of PARP activity in tumor of immunocompromised mouse xenografted with human MDA-MB-436 cells harboring BRCA1 mutant assessed as incorporation of [3H]NAD in PAR chains in response to nicked DNA at 50 to 100 mg/kg, po measured after 24 hrs | Homo sapiens | 1 | ALA3425485 | organism-based format | Scientific Literature | |
8. | ALA3429725 | F | Inhibition of PARP activity in tumor of immunocompromised mouse xenografted with BRCA2-deficient human Capan1 cells assessed as incorporation of [3H]NAD in PAR chains in response to nicked DNA at 50 to 100 mg/kg, po measured after 24 hrs | Homo sapiens | 1 | ALA3425485 | organism-based format | Scientific Literature | |
9. | ALA3429726 | B | Inhibition of PARP-mediated incorporation of [3H]NAD in PAR chains in response to nicked DNA in human PBMC after 24 hrs | Homo sapiens | 1 | ALA3425485 | protein format | Scientific Literature | |
10. | ALA3429727 | B | Inhibition of PARP in human LoVo cells assessed as inhibition of hydrogen peroxide-induced PARylation treated for 30 mins prior to incubation with H2O2 for 5 mins by fluorescence analysis | Homo sapiens | 1 | ALA3425485 | cell-based format | Scientific Literature | |
11. | ALA3743816 | B | Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 21 | ALA3739394 | cell-based format | Scientific Literature | |
12. | ALA3743857 | B | Inhibition of PARP in human MCF7 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 1 | ALA3739394 | cell-based format | Scientific Literature | |
13. | ALA3743858 | B | Inhibition of PARP in multi-drug resistant human MCF7 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 1 | ALA3739394 | cell-based format | Scientific Literature | |
14. | ALA3745011 | B | Inhibition of PARP in human MDA-MB-468 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 1 | ALA3739394 | cell-based format | Scientific Literature | |
15. | ALA3745012 | B | Inhibition of PARP in human HCC1806 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 1 | ALA3739394 | cell-based format | Scientific Literature | |
16. | ALA3745013 | B | Inhibition of PARP in human MDA-MB-157 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 1 | ALA3739394 | cell-based format | Scientific Literature | |
17. | ALA3767926 | B | Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assay | Homo sapiens | 39 | ALA3763037 | cell-based format | Scientific Literature |