# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3398692 | B | Inhibition of OGG1 (unknown origin) pre-incubated with compound for 10 mins followed by addition of 1,N6 ethenoadenine containing 32P-labeled duplex oligonucleotide substrates at 20 to 40 uM by gel-based excision activity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
2. | ALA3398697 | B | Inhibition of OGG1 in human A549 cells assessed as reduction in DNA repair at 200 and 300 uM using 8-oxodG-containing M13mp18 plasmids by plasmid based in-cell repair assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA3398699 | B | Inhibition of OGG1 in human HeLa cells assessed as reduction in DNA repair at 200 and 300 uM using 8-oxodG-containing M13mp18 plasmids by plasmid based in-cell repair assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA4422180 | B | Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay | Homo sapiens | 20 | single protein format | Patent Bioactivity Data | ||
5. | ALA4422181 | B | Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by PAGE-based cleavage assay | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
6. | ALA4422185 | B | Inhibition of human OGG1 at 0.08 to 8 uM incubated for 30 mins using 8-oxo-Gua-containing substrate by PAGE-based cleavage assay | Homo sapiens | 1 | single protein format | Patent Bioactivity Data | ||
7. | ALA4422186 | B | Inhibition of human OGG1 assessed as reduction in AP lyase activity using AP-containing substrate | Homo sapiens | 7 | single protein format | Patent Bioactivity Data | ||
8. | ALA4422187 | B | Inhibition of human OGG1 assessed as reduction in free 8-oxo-Gua release using gamma-irradiated calf thymus DNA substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 7 | single protein format | Patent Bioactivity Data | ||
9. | ALA4422188 | B | Inhibition of human OGG1 assessed as reduction in free Inhibition of human OGG1 assessed as reduction in free FapyGua release using gamma-irradiated calf thymus DNA substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 7 | single protein format | Patent Bioactivity Data | ||
10. | ALA4422204 | B | Inhibition of human OGG1 assessed as protection against NaOH-mediated strand cleavage using AP-containing substrate (Rvb = 100%) | Homo sapiens | 7 | single protein format | Patent Bioactivity Data | ||
11. | ALA4422207 | B | Inhibition of human OGG1 binding to 8-oxo-Gua substrate using compound pre-incubated with enzyme for 5 to 10 mins before substrate addition and further incubated for 5 mins by native gel electrophoresis based by gel-shift assay | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
12. | ALA4422208 | B | Inhibition of human OGG1 binding to AP site containing substrate assessed as reduction in AP site binding using compound pre-incubated with enzyme for 5 to 10 mins before substrate addition and further incubated for 5 mins by native gel electrophoresis based by gel-shift assay | Homo sapiens | 1 | single protein format | Patent Bioactivity Data | ||
13. | ALA4422209 | B | Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates at 10 uM using 8-oxo-Gua substrate in presence of sodium cyno-borohydride by gel electrophoresis method | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
14. | ALA4422210 | B | Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates at 10 uM using AP site containing substrate in presence of sodium cyno-borohydride by gel electrophoresis method | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
15. | ALA4422211 | B | Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates using 8-oxo-Gua substrate by measuring concentration of compound needed to reduce borohydride trapping by 50% in presence of sodium cyno-borohydride by gel electrophoresis method | Homo sapiens | 2 | single protein format | Patent Bioactivity Data | ||
16. | ALA4422212 | B | Inhibition of human OGG1 catalytic activity assessed as reduction trapping of substrates using AP site containing substrate by measuring concentration of compound needed to reduce borohydride trapping by 50% in presence of sodium cyno-borohydride by gel electrophoresis method | Homo sapiens | 2 | single protein format | Patent Bioactivity Data |