# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3404160 | B | Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in presence of S-adenosylmethionine | Homo sapiens | 8 | ALA3399996 | single protein format | Scientific Literature | |
2. | ALA4136615 | B | Inhibition of human recombinant CBS assessed as reduction in H2S production at 40 uM using AzMC probe by fluorescence based assay | Homo sapiens | 1 | ALA4130591 | single protein format | Scientific Literature | |
3. | ALA4138486 | B | Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay | Homo sapiens | 1 | ALA4138050 | single protein format | Scientific Literature | |
4. | ALA4138488 | B | Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition | Homo sapiens | 12 | ALA4138050 | single protein format | Scientific Literature | |
5. | ALA4138491 | B | Reversible inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production at 100 uM preincubated for 1 hr followed by ultrafiltration for 5 times | Homo sapiens | 11 | ALA4138050 | single protein format | Scientific Literature | |
6. | ALA4258355 | B | Competitive inhibition of full-length GST-fused human CBS up to 10 uM using S-methylcysteine as substrate by Lineweaver-burk plot analysis | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
7. | ALA4258356 | B | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 2 | ALA4257472 | single protein format | Scientific Literature | |
8. | ALA4258357 | B | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 2 | ALA4257472 | single protein format | Scientific Literature | |
9. | ALA4258358 | B | Non-competitive inhibition of full-length GST-fused human CBS using S-methylcysteine as substrate by Lineweaver-burk plot analysis | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
10. | ALA4258359 | B | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition measured in presence of Triton X-100 | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
11. | ALA4258360 | B | Inhibition of human CBS T193A mutant assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
12. | ALA4258361 | B | Inhibition of human CBS N194A mutant assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
13. | ALA4258362 | B | Inhibition of human CBS H203A mutant assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
14. | ALA4258363 | B | Inhibition of human CBS Y223A mutant assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
15. | ALA4258364 | B | Inhibition of human CBS Y308A mutant assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | Homo sapiens | 1 | ALA4257472 | single protein format | Scientific Literature | |
16. | ALA4675264 | B | Inhibition of wild type human CBS expressed in HEK293T cells assessed as reduction in H2S contents | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
17. | ALA4675294 | B | Inhibition of CBS (unknown origin) by AzMC based fluorescence assay | Homo sapiens | 1 | ALA4673222 | single protein format | Scientific Literature | |
18. | ALA4675295 | B | Inhibition of human CBS by methylene blue method | Homo sapiens | 1 | ALA4673222 | single protein format | Scientific Literature | |
19. | ALA4675297 | B | Inhibition of CBS (unknown origin) by methylene blue method | Homo sapiens | 1 | ALA4673222 | single protein format | Scientific Literature | |
20. | ALA4680965 | B | Binding affinity to human CBS by PLP fluorescence-based screening assay | Homo sapiens | 2 | ALA4680078 | single protein format | Scientific Literature |