# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3413306 | Binding | Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Mus musculus | 5 | ALA3407478 | single protein format | Scientific Literature | |
2. | ALA3414281 | Binding | Inhibition of mouse KMO | Mus musculus | 1 | ALA3407478 | single protein format | Scientific Literature | |
3. | ALA3536662 | ADME | Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysis | Mus musculus | 4 | ALA3526063 | single protein format | Scientific Literature | |
4. | ALA3536665 | ADME | Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysis in presence of 3 mg/ml plasma protein | Mus musculus | 1 | ALA3526063 | single protein format | Scientific Literature | |
5. | ALA4679423 | Binding | Inhibition of mouse liver mitochondrial KMO using kynurenine as substrate by measuring the 3-HK formation preincubated for 5 mins followed by substrate addition and measured after 40 mins by LC-MS/MS analysis | Mus musculus | 1 | ALA4673377 | mitochondrion format | Scientific Literature | |
6. | ALA4679435 | Binding | Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation at 100 nM using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis relative to control | Mus musculus | 2 | ALA4673377 | mitochondrion format | Scientific Literature | |
7. | ALA4679436 | Binding | Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis | Mus musculus | 20 | ALA4673377 | mitochondrion format | Scientific Literature |