# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3592250 | Binding | Inhibition of interaction of myostatin (unknown origin)/ActRIIA-ECD complex with ALK4-ECD-Fc at 25 uM after 120 secs by competitive binding/ Blitz binding assay | Homo sapiens | 1 | ALA3588747 | single protein format | Scientific Literature | |
2. | ALA3413636 | Binding | Inhibition of human recombinant myostatin pre-incubated with 5 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay | Homo sapiens | 1 | ALA3407500 | cell-based format | Scientific Literature | |
3. | ALA3413637 | Binding | Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay | Homo sapiens | 4 | ALA3407500 | cell-based format | Scientific Literature | |
4. | ALA3413638 | Binding | Inhibition of human recombinant myostatin pre-incubated with 5 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated Smad2 phosphorylation by Western blotting method | Homo sapiens | 1 | ALA3407500 | cell-based format | Scientific Literature | |
5. | ALA3413639 | Binding | Inhibition of human recombinant myostatin pre-incubated with 30 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated Smad2 phosphorylation by Western blotting method | Homo sapiens | 5 | ALA3407500 | cell-based format | Scientific Literature | |
6. | ALA3413641 | Binding | Inhibition of human recombinant myostatin pre-incubated with 30 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay | Homo sapiens | 10 | ALA3407500 | cell-based format | Scientific Literature | |
7. | ALA3413642 | Binding | Binding affinity to recombinant myostatin (unknown origin) by surface plasmon resonance assay | Homo sapiens | 3 | ALA3407500 | single protein format | Scientific Literature | |
8. | ALA3871202 | Binding | Inhibition of human recombinant myostatin expressed in HEK293 cells at 10 uM after 4 hrs by SBE4 based luciferase reporter gene assay | Homo sapiens | 29 | ALA3870362 | cell-based format | Scientific Literature | |
9. | ALA3871203 | Binding | Inhibition of human recombinant myostatin expressed in HEK293 cells at 3 uM after 4 hrs by SBE4 based luciferase reporter gene assay | Homo sapiens | 3 | ALA3870362 | cell-based format | Scientific Literature | |
10. | ALA3871204 | Binding | Inhibition of human recombinant myostatin expressed in HEK293 cells after 4 hrs by SBE4 based luciferase reporter gene assay | Homo sapiens | 1 | ALA3870362 | cell-based format | Scientific Literature | |
11. | ALA4036929 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 3 uM after 4 hrs by dual-luciferase reporter gene assay | Homo sapiens | 16 | ALA4033771 | cell-based format | Scientific Literature | |
12. | ALA4036930 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 1 uM after 4 hrs by dual-luciferase reporter gene assay | Homo sapiens | 12 | ALA4033771 | cell-based format | Scientific Literature | |
13. | ALA4036931 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells after 4 hrs by dual-luciferase reporter gene assay | Homo sapiens | 3 | ALA4033771 | cell-based format | Scientific Literature | |
14. | ALA4036932 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 5 uM after 4 hrs by dual-luciferase reporter gene assay relative to control | Homo sapiens | 2 | ALA4033771 | cell-based format | Scientific Literature | |
15. | ALA4036933 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 2.5 uM after 4 hrs by dual-luciferase reporter gene assay relative to control | Homo sapiens | 2 | ALA4033771 | cell-based format | Scientific Literature | |
16. | ALA4036934 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 1.25 uM after 4 hrs by dual-luciferase reporter gene assay relative to control | Homo sapiens | 2 | ALA4033771 | cell-based format | Scientific Literature | |
17. | ALA4036935 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 0.63 uM after 4 hrs by dual-luciferase reporter gene assay relative to control | Homo sapiens | 2 | ALA4033771 | cell-based format | Scientific Literature | |
18. | ALA4036936 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 0.32 uM after 4 hrs by dual-luciferase reporter gene assay relative to control | Homo sapiens | 1 | ALA4033771 | cell-based format | Scientific Literature | |
19. | ALA4036937 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 0.16 uM after 4 hrs by dual-luciferase reporter gene assay relative to control | Homo sapiens | 1 | ALA4033771 | cell-based format | Scientific Literature | |
20. | ALA4036938 | Binding | Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at <= 0.08 uM after 4 hrs by dual-luciferase reporter gene assay | Homo sapiens | 1 | ALA4033771 | cell-based format | Scientific Literature |