# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2149519 | F | Agonist activity at LXRalpha/RXRalpha expressed in human Cos1 cells after 18 hrs by SEAP reporter gene assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
2. | ALA1227772 | B | Transactivation of LXRalpha/RXRalpha | 3 | protein complex format | Scientific Literature | |||
3. | ALA1696527 | F | Agonist activity at LXRalpha/RXRalpha transfected in human COS1 cells at 10'-7 to 10'-6 M after 18 hrs by luciferase reporter gene transactivation assay | 3 | cell-based format | Scientific Literature | |||
4. | ALA2341869 | B | Transactivation of LXRalpha/RXRalpha (unknown origin) by luciferase reporter gene assay relative to carba-T0901317 | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
5. | ALA3377012 | B | Binding affinity to LXRalpha-RXRalpha heterodimer (unknown origin) expressed in insect cells by scintillation proximity assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
6. | ALA3370750 | B | Antagonist activity against RXRalpha/LXRalpha ligand binding domain (unknown origin) expressed in human HEK293T cells assessed as inhibition of 9-cis-RA/T09-induced receptor transactivation at 2 and 10 uM after 18 hrs by luciferase reporter gene based mammalian one-hybrid assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA3611849 | B | Binding affinity to His-LXRalpha/FLAG-RXRalpha (unknown origin) by FITC-labeled T0901317 based fluorescence polarization assay | Homo sapiens | 12 | protein complex format | Scientific Literature | ||
8. | ALA3610230 | B | Agonist activity at His-LXRalpha/FLAG-RXRalpha (unknown origin) assessed as recruitment of PGC1alpha peptide (130 to 154 residues) pre-incubated for 60 mins before PGC1alpha addition followed by one night of incubation by FRET assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
9. | ALA3610231 | B | Agonist activity at His-LXRalpha/FLAG-RXRalpha (unknown origin) assessed as recruitment of ASC2 peptide (1481 to 1510 residues) pre-incubated for 60 mins before ASC2 peptide addition followed by one night of incubation by FRET assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
10. | ALA3868515 | B | Displacement of [3H]-24,25-epoxycholesterol from human LXRalpha/RXRalpha expressed in baculovirus infected Sf9 cells by scintillation proximity analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
11. | ALA4430357 | A | Agonist activity at human RXRalpha/LXRalpha expressed in human HCT116 cells assessed as reduction in SREBP-mediated transcription activity at 100 nM incubated for 24 hrs by luciferase reporter gene assay relative to bexarotene | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
12. | ALA4430358 | A | Agonist activity at human RXRalpha/LXRalpha expressed in human HCT116 cells assessed as reduction in SREBP-mediated transcription activity at 100 nM incubated for 24 hrs by luciferase reporter gene assay in presence of 100 nM LXR agonist TO901317 relative to bexarotene | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
13. | ALA4686879 | A | Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
14. | ALA4686881 | A | Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay relative to GW3965 | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
15. | ALA4775412 | B | Competitive antagonist activity at human LXR-alpha/RXRA expressed in African green monkey COS7 cells assessed as reduction in bexarotene-induced receptor activation by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4775416 | B | Competitive antagonist activity at human LXR-alpha/RXRA expressed in African green monkey COS7 cells assessed as reduction in LXR agonist T0901317 -induced receptor activation at 10 uM by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature |