| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3420554 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HeLa cells assessed as induction of p21 gene expression at 10 uM after 15 hrs by luciferase reporter gene assay relative to HDAC1 inhibitor SNDX-275 | Homo sapiens | 8 | ALA3414430 | cell-based format | Scientific Literature | |
| 2. | ALA3420555 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HeLa cells assessed as induction of p21 gene expression at 3 to 10 uM after 15 hrs by luciferase reporter gene assay | Homo sapiens | 2 | ALA3414430 | cell-based format | Scientific Literature | |
| 3. | ALA3420556 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HeLa cells assessed as induction of p21 gene expression at 10 uM after 15 hrs by luciferase reporter gene assay | Homo sapiens | 2 | ALA3414430 | cell-based format | Scientific Literature | |
| 4. | ALA4017020 | B | Inhibition of HDAC1/2/3/6 in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 500 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 5. | ALA4017021 | B | Inhibition of HDAC1/2/3/6 in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 6. | ALA4017022 | B | Inhibition of HDAC1/2/3/6 in human A2780cisR cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 7. | ALA4017023 | B | Inhibition of HDAC1/2/3/6 in human Cal27 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 8. | ALA4017035 | B | Inhibition of HDAC1/2/3/6 in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 250 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 9. | ALA4017036 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 250 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 10. | ALA4017038 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 500 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 11. | ALA4017040 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 1 uM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 12. | ALA4017041 | B | Inhibition of HDAC1/2/3/6 in human Cal27 cells assessed as potentiation of cisplatin-induced apoptosis at 250 to 500 nM preincubated for 48 hrs followed by cisplatin addition by flow cytomertry assay | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 13. | ALA4017042 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced apoptosis at 250 to 500 nM preincubated for 48 hrs followed by cisplatin addition by flow cytomertry assay | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 14. | ALA4017045 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 15. | ALA4017051 | B | Inhibition of HDAC1/2/3/6 in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 16. | ALA4017052 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced cytotoxicity preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature |
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