| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3509253 | A | Enzyme kinetics constant (Km value) for CYP4F3B was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 2. | ALA3509262 | A | Enzyme kinetics constant (Vmax value) for CYP4F3B was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 3. | ALA3509271 | A | Metabolic clearance (ul.min.nmol-1 CYP) of aliskiren hemifumarate for CYP4F3B was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 4. | ALA3541893 | A | Drug metabolism assessed as human CYP4F3A-mediated compound formation from 5 uM [14C]boceprevir after 120 mins by LC-MS/FSA method relative to total [14C]boceprevir | Homo sapiens | 22 | ALA3526141 | single protein format | Scientific Literature | |
| 5. | ALA3535833 | A | Activity at human recombinant CYP4F3A expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation at 5 to 100 M after 30 mins by HPLC-RA analysis | Homo sapiens | 1 | ALA3525920 | cell-based format | Scientific Literature | |
| 6. | ALA3532999 | A | Activity at human recombinant CYP4F3B expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as relative abundance of compound formation treated with [14C]fingolimod at 100 uM after 30 mins by HPLC-RA analysis | Homo sapiens | 1 | ALA3525920 | cell-based format | Scientific Literature | |
| 7. | ALA3531667 | A | Activity of human recombinant CYP4F3B assessed as enzyme-mediated drug metabolism treated with 25 uM vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 8. | ALA3532136 | A | Activity of human recombinant CYP4F3A assessed as enzyme-mediated drug metabolism treated with 25 uM vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 9. | ALA3529564 | A | Activity of human recombinant CYP4F3A assessed as enzyme-mediated (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 10. | ALA3529565 | A | Drug level assessed as human recombinant CYP4F3A-mediated drug metabolism treated with 25 uM [14C]vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 11. | ALA3529777 | A | Activity of human recombinant CYP4F3A assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 12. | ALA3529778 | A | Activity of human recombinant CYP4F3B assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 13. | ALA4185368 | A | Substrate activity at recombinant human CYP4F3B expressed in bactosomes assessed as CYP4F3B-mediated benzoic acid (6R,7S)-2,6,10-trihydroxy-1,3,11,12-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cycloocten-5-yl ester formation at 5 to 50 uM after 30 mins in presence of NADPH by UFLC-DAD analysis | Homo sapiens | 1 | ALA4184142 | assay format | Scientific Literature | |
| 14. | ALA4406423 | A | Inhibition of recombinant human CYP4F3A expressed in baculovirus infected insect cells at 30 uM using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 6 | ALA4402606 | cell-based format | Scientific Literature | |
| 15. | ALA4406424 | A | Inhibition of recombinant human CYP4F3B expressed in baculovirus infected insect cells at 30 uM using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 6 | ALA4402606 | cell-based format | Scientific Literature | |
| 16. | ALA4406430 | A | Inhibition of recombinant human CYP4F3A expressed in baculovirus infected insect cells using Luc-4F2/3 as substrate after 10 mins in presence of NADPH by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | ALA4402606 | cell-based format | Scientific Literature | |
| 17. | ALA4406431 | A | Inhibition of recombinant human CYP4F3B expressed in baculovirus infected insect cells using Luc-4F2/3 as substrate after 10 mins in presence of NADPH by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | ALA4402606 | cell-based format | Scientific Literature | |
| 18. | ALA4406436 | A | Inhibition of recombinant human CYP4F3A expressed in baculovirus infected insect cells using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | ALA4402606 | cell-based format | Scientific Literature | |
| 19. | ALA4406437 | A | Inhibition of recombinant human CYP4F3B expressed in baculovirus infected insect cells using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | ALA4402606 | cell-based format | Scientific Literature | |
| 20. | ALA4406441 | A | Ratio of IC50 for inhibition of recombinant human CYP4F3A expressed in baculovirus infected insect cells using Luc-4F2/3 as substrate after 10 mins in presence of NADPH to IC50 for inhibition of recombinant human CYP4F3A expressed in baculovirus infected insect cells using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | ALA4402606 | cell-based format | Scientific Literature |
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