| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3541895 | A | Drug metabolism assessed as human CYP4F12-mediated compound formation from 5 to 20 uM [14C]boceprevir after 120 mins by LC-MS/FSA method relative to total [14C]boceprevir | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA3532909 | A | Activity at human recombinant CYP4F12 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as relative abundance of compound formation treated with [14C]fingolimod at 20 uM after 30 mins by HPLC-RA analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA3535849 | A | Activity at human recombinant CYP4F12 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes at 10 uM by HPLC-RA analysis in presence of CYP4F2 and CYP4F12 inhibitor ketoconazole | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3533002 | A | Activity at human recombinant CYP4F12 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation at 5 to 100 uM after 30 mins by HPLC-RA analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3531668 | A | Activity of human recombinant CYP4F12 assessed as enzyme-mediated drug metabolism treated with 25 uM vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3531396 | A | Activity of human recombinant CYP4F12 assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4406425 | A | Inhibition of recombinant human CYP4F12 expressed in baculovirus infected insect cells at 30 uM using Luc-BE as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4406432 | A | Inhibition of recombinant human CYP4F12 expressed in baculovirus infected insect cells using Luc-BE as substrate after 10 mins in presence of NADPH by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4406438 | A | Inhibition of recombinant human CYP4F12 expressed in baculovirus infected insect cells using Luc-BE as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4406443 | A | Ratio of IC50 for inhibition of recombinant human CYP4F12 expressed in baculovirus infected insect cells using Luc-BE as substrate after 10 mins in presence of NADPH to IC50 for inhibition of recombinant human CYP4F12 expressed in baculovirus infected insect cells using Luc-BE as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5238695 | A | Inhibition of human recombinant CYP4F12 using Luciferin ME EGE as substrate incubated for 30 mins in presence of NADPH by luminescence based assay | Homo sapiens | 2 | single protein format | Scientific Literature |
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