# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579719 | B | Agonist activity at GPR34 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay | Homo sapiens | 52 | cell-based format | Scientific Literature | ||
2. | ALA3721014 | F | Antagonist activity against human lung GPR34 expressed in CHO cells co-expressing Galpha116 assessed as inhibition of lysophosphatidyl serine-induced increase in intracellular calcium level pre-incubated before lysophosphatidyl serine addition and measured after 180 secs by Fluo 3-AM dye based fluorescent assay | Homo sapiens | 79 | cell-based format | Patent Bioactivity Data | ||
3. | ALA3721015 | F | Inverse agonist activity at human GPR34 expressed in CHO cells assessed as inhibition of lysophosphatidyl serine-induced reduction in cAMP accumulation by measuring cAMP level at 10 uM incubated for 30 mins before lysophosphatidyl serine addition by EIA method relative to untreated control | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4014238 | B | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha release after 1 hr | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
5. | ALA4014239 | B | Intrinsic activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha release after 1 hr relative to O-(Hydroxy(((2R,3R)-2-(((3-(2-((3-phenoxybenzyl)oxy)phenyl)- propanoyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)phosphoryl)- L-serine | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
6. | ALA4014241 | B | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha release after 1 hr relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
7. | ALA4729134 | B | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
8. | ALA4729135 | B | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
9. | ALA4883447 | B | PRESTO-Tango GPCRome screening (GPR34) | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt |