| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4187427 | B | Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B catalytic fragment (Met1 to Leu543 residues) assessed as reduction in glucosyltransferase domain UDP-glucose hydrolysis activity using UDP-glucose and ADP Alexa633 tracer incubated fore 3 hrs by fluorescence polarization assay | Clostridioides difficile | 45 | single protein format | Scientific Literature | ||
| 2. | ALA4187428 | B | Inhibition of Clostridium difficile toxin B transfected in CHO cells assessed as reduction in caspase 3/7 activation pre-incubated for 1 hr before TcdB addition by luminescence based assay1 | Clostridioides difficile | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA4323656 | B | Inhibition of Clostridium difficile toxin B | Clostridioides difficile | 1 | single protein format | Scientific Literature | ||
| 4. | ALA4328867 | B | Inhibition of Clostridium difficile toxin B transfected in CHO cells assessed as reduction in caspase 3/7 activation pre-incubated for 1 hr before TcdB addition by luminescence based assay | Clostridioides difficile | 35 | cell-based format | Scientific Literature | ||
| 5. | ALA4328869 | B | Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B glucosyltransferase domain assessed as reduction in UDP-glucose hydrolysis activity using UDP-glucose substrate and ADP Alexa633 tracer incubated for 3 hrs by fluorescence polarization assay | 33 | single protein format | Scientific Literature |
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