| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5254919 | B | Binding affinity to human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) assessed as thermal stabilization by measuring melting temperature by DSF assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA3583018 | B | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 3. | ALA4017390 | B | Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 4. | ALA4017391 | B | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 5. | ALA4017392 | B | Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) assessed as induction of protein oligomerization at 1:1 to 10:1 protein to compound ratio by 1H-15N 2D HMQC NMR spectroscopic analysis | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 6. | ALA4017393 | B | Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) assessed as induction of protein oligomerization at 1:1 to protein to compound ratio by 1H-15N 2D HMQC NMR spectroscopic analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 7. | ALA4017394 | B | Binding affinity to human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) assessed as induction of protein dimerization at 1:3 protein to compound ratio after 10 mins by gel filteration assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 8. | ALA4017395 | B | Binding affinity to [15N-Val]-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 9. | ALA4017396 | B | Binding affinity to [15N-Tyr]-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 10. | ALA4263391 | B | Inhibition of PD-L1 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA4307476 | B | Inhibition of PDL1 in human MDA-MB-21 cells assessed as recovery of mouse splenocyte proliferation at 100 nM by CFSE-based FACS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4307479 | B | Binding affinity to biotinylated recombinant human C-terminal FC/Avi-tagged PDL1 (19 to 239 residues) at 0.03 to 30 uM by SPR analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA4312958 | B | Binding affinity to 15N-labelled human PDL1 assessed as induction of oligomerization by 1H-NMR spectra analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA4312959 | B | Binding affinity to 15N-labelled human PDL1 assessed as induction of protein oligomerization by 1H-15N HMQC spectra analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA4330219 | B | Binding affinity to Fc-labeled human PDL1 expressed in Escherichia coli by SPR spectroscopy | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 16. | ALA4330220 | B | Binding affinity to biotinylated PDL1 (unknown origin) expressed in Escherichia coli OmpX membrane after 45 mins by SAPE-fluorescence based flow cytometry | Homo sapiens | 1 | cell membrane format | Scientific Literature | ||
| 17. | ALA4347537 | B | Binding affinity to PDL1 (unknown origin) assessed as change in melting temperature at 100 uM by fluorescence based real time RT-PCR analysis | Homo sapiens | 18 | single protein format | Scientific Literature | ||
| 18. | ALA4424698 | B | Binding affinity to human 15N-labelled 6His-tagged PDL1 IgV domain H140E mutant (18 to 134 residues) expressed in Escherichia coli BL21 (DE3) by 1D-1H NMR spectroscopy | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 19. | ALA4424699 | B | Displacement of 15N-labelled PD1 from human 15N-labelled 6His-tagged PDL1 IgV domain H140E mutant (18 to 134 residues) at 800 uM assessed as rescue signal intensity by HMQC spectra analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 20. | ALA4424700 | B | Displacement of 15N-labelled PD1 from human 15N-labelled 6His-tagged PDL1 IgV domain H140E mutant (18 to 134 residues) at 2 mM assessed as rescue signal intensity by HMQC spectra analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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