| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1225690 | B | Inhibition of NFkappa signaling in in mouse macrophages assessed as reduction in RANKL-induced IkapppaB phosphorylation at 10 uM pretreated for 1 hr before RANKL challenge by Western blotting | Mus musculus | 2 | single protein format | Scientific Literature | ||
| 2. | ALA1225695 | B | Inhibition of NFkappa signaling in in mouse macrophages assessed as reduction in RANKL-induced IkapppaB phosphorylation at 50 uM pretreated for 1 hr before RANKL challenge by Western blotting | Mus musculus | 2 | single protein format | Scientific Literature | ||
| 3. | ALA3383355 | B | Inhibition of RANKL-stimulated IkappaBalpha degradation in ICR mouse BMMC at 1 to 10 uM incubated for 4 hrs by Western blotting method | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3383358 | F | Inhibition of RANKL-induced c-FOS mRNA expression in ICR mouse BMMC at 5 uM incubated for 12 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 5. | ALA3383360 | B | Inhibition of RANKL-stimulated ERK phosphorylation in ICR mouse BMMC at 1 to 10 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3383361 | B | Inhibition of RANKL-stimulated JNK phosphorylation in ICR mouse BMMC at 1 to 10 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 7. | ALA3383363 | F | Inhibition of RANKL-induced NFATc1 mRNA expression in ICR mouse BMMC at 5 uM incubated for 12 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3383364 | F | Inhibition of RANKL-induced c-FOS protein expression in ICR mouse BMMC at 1 to 10 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3383365 | F | Inhibition of RANKL-induced NFATc1 protein expression in ICR mouse BMMC at 1 to 10 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3383366 | B | Inhibition of RANKL-stimulated JNK in ICR mouse BMMC assessed as reduction in c-Jun phosphorylation at 1 to 20 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3383934 | F | Inhibition of RANKL-induced c-FOS protein expression in ICR mouse BMMC at 1 to 20 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 12. | ALA3383935 | F | Inhibition of RANKL-induced NFATc1 protein expression in ICR mouse BMMC at 1 to 20 uM incubated for 12 hrs by Western blotting method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 13. | ALA3578971 | F | Inhibition of RANKL-induced fusion of preosteoclast derived from ICR mouse bone marrow-derived macrophages assessed as formation of tartrate-resistant acid phosphatase-positive multinucleated osteoclast preincubated for 30 mins with M-CSF followed by RANKL induction measured after 1 day by TRAP staining | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3578973 | F | Inhibition of RANKL-induced migration of preosteoclast derived from ICR mouse bone marrow-derived macrophages after 8 hrs by Boyden chamber assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3583002 | F | Antiosteoclastogenic activity in ICR mouse bone marrow-derived preosteoclasts assessed as inhibition of RANKL/M-CSF-induced osteoclast formation at 10 uM after 5 days by TRAP staining | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3583006 | B | Inhibition of RANKL-induced IKK phosphorylation in mouse RAW264.7 cells at 10 uM preincubated for 2 hrs followed by RANKL induction measured over 60 mins by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3599997 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as reduction of TRAP-positive multinucleated cells at 5 uM after 4 days by light microscopic analysis relative to control | Mus musculus | 12 | cell-based format | Scientific Literature | ||
| 18. | ALA3599999 | B | Inhibition of recombinant mouse RANKL-induced TRAP activity in mouse RAW264.7 cells using 4-nitrophenyl phosphate as TRAP substrate preincubated for 4 days followed by substrate addition measured after 15 mins by ELISA reader analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA3600000 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as suppression of NFATc1 mRNA expression at 2.5 to 5 uM preincubated for 1 hr followed by RANKL addition measured after 24 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA3600001 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as suppression of c-fos mRNA expression at 2.5 to 5 uM preincubated for 1 hr followed by RANKL addition measured after 24 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature |
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