# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3607813 | B | Binding affinity to human IgG1-fused human Siglec-7-FC (Gln19 to Gly357 residues) assessed as inhibition Siglec-7-Fc binding to to RBC pre-incubated for 10 mins before 20 mins incubation with RBCs by flow cytometry | Homo sapiens | 2 | ALA3603750 | single protein format | Scientific Literature | |
2. | ALA3607814 | B | Potency index, ratio of IC50 for compound-1 to IC50 for test compound for binding affinity to human IgG1-fused human Siglec-7-FC (Gln19 to Gly357 residues) assessed as inhibition Siglec-7-Fc binding to to RBC pre-incubated for 10 mins before 20 mins incubation with RBCs by flow cytometry | Homo sapiens | 10 | ALA3603750 | single protein format | Scientific Literature | |
3. | ALA3993868 | B | Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC addition measured after 20 mins by FACS analysis relative to sodium (4S,5R,6R)-5-acetamido-4-hydroxy-2-methoxy-6-((1R,2R)-1,2,3 trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylate | Homo sapiens | 36 | ALA3992537 | single protein format | Scientific Literature | |
4. | ALA3993869 | B | Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC addition measured after 20 mins by FACS analysis | Homo sapiens | 6 | ALA3992537 | single protein format | Scientific Literature | |
5. | ALA3993872 | B | Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA | Homo sapiens | 4 | ALA3992537 | single protein format | Scientific Literature | |
6. | ALA3993873 | B | Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA relative to 3'sialyllactose | Homo sapiens | 3 | ALA3992537 | single protein format | Scientific Literature | |
7. | ALA3993876 | B | Binding affinity to Siglec-7 in IL-2 activated human NK cells assessed as increase in NK cell-mediated 51Cr labeled human MEL1106 cell lysis by measuring 51Cr release preincubated for 15 mins followed by MEL1106 cell addition measured after 4 hrs by gamma-counting method | Homo sapiens | 1 | ALA3992537 | assay format | Scientific Literature | |
8. | ALA3993877 | B | Ratio of 3'sialyllactose Kd to relative inhibitory potency of test compound for human IgG1-fused Siglec-7-Fc by ELISA | Homo sapiens | 2 | ALA3992537 | single protein format | Scientific Literature | |
9. | ALA3993879 | B | Binding affinity to human IgG1-fused Siglec-7-Fc | Homo sapiens | 3 | ALA3992537 | single protein format | Scientific Literature | |
10. | ALA4368158 | B | Binding affinity to recombinant human Fc-fused siglec-7 by fluorescence based glycan microarray analysis | Homo sapiens | 9 | ALA4364321 | single protein format | Scientific Literature | |
11. | ALA4368162 | B | Binding affinity to recombinant human Fc-fused siglec-7 after 1 hr by fluorescence based glycan microarray analysis | Homo sapiens | 6 | ALA4364321 | single protein format | Scientific Literature | |
12. | ALA4368163 | B | Binding affinity to recombinant human Fc-fused siglec-7 expressed in CHO cells measured over 180 secs | Homo sapiens | 1 | ALA4364321 | cell-based format | Scientific Literature |