| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3614737 | B | Inhibition of sphingomyelin synthase-1 (unknown origin) expressed in HeLa cells using C6-NBD-Cer and DMPC as substrate after 2 hrs by fluorescent HPLC-based analysis | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 2. | ALA3615026 | B | Ratio of D609 IC50 to compound IC50 for sphingomyelin synthase-1 (unknown origin) expressed in HeLa cells using C6-NBD-Cer and DMPC as substrate after 2 hrs by fluorescent HPLC-based analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4036690 | B | Inhibition of purified SMS1 (unknown origin) at 20 umol/L pre-incubated for 5 mins followed by DMPC and C6-NBD-ceramide addition and measured after 30 mins by HPLC method | Homo sapiens | 33 | single protein format | Scientific Literature | ||
| 4. | ALA4036691 | B | Inhibition of purified SMS1 (unknown origin) at 100 umol/L pre-incubated for 5 mins followed by DMPC and C6-NBD-ceramide addition and measured after 30 mins by HPLC method | Homo sapiens | 19 | single protein format | Scientific Literature | ||
| 5. | ALA4139285 | A | Inhibition of full length C-terminal FLAG tagged human SMS1 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincubated for 60 mins followed by substrate addition measured after 30 mins by RapidFire/mass spectrometry assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4139291 | A | Inhibition of human SMS1 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4200194 | B | Inhibition of human SMS1 at 50 uM using C6-NBD-ceramide and DMPC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by HPLC analysis relative to control | Homo sapiens | 32 | single protein format | Scientific Literature | ||
| 8. | ALA4200195 | B | Inhibition of human SMS1 using C6-NBD-ceramide and DMPC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by HPLC analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 9. | ALA4399503 | B | Inhibition of SMS1 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4399505 | B | Inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs by HPLC analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4399507 | B | Noncompetitive inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs by HPLC analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4412722 | B | Inhibition of purified SMS1 (unknown origin) using C6-NBD-Ceramide and DMPC as substrates preincubated for 5 mins followed by substrate addition and measured after 30 mins by TLC or HPLC method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4628268 | A | Inhibition of human recombinant C-terminal FLAG-tagged SMS1 expressed in mammalian expression system using C14-phosphatidylcholineD72 and C17-ceramide pre-incubated for 60 mins followed by incubation with substrate for 30 mins measured by RapidFire/MS assay | Homo sapiens | 17 | assay format | Scientific Literature |
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