# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3630806 | Binding | Inhibition of human IDO2 | Homo sapiens | 1 | ALA3627665 | single protein format | Scientific Literature | |
2. | ALA4356124 | Binding | Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue dye based microplate reader analysis | Homo sapiens | 13 | ALA4354812 | assay format | Scientific Literature | |
3. | ALA4356127 | Binding | Inhibition of human IDO2 transfected in human U87MG cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated with for 6 hrs | Homo sapiens | 13 | ALA4354812 | cell-based format | Scientific Literature | |
4. | ALA4356132 | Binding | Mixed competitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 2 | ALA4354812 | assay format | Scientific Literature | |
5. | ALA4356133 | Binding | Uncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 9 | ALA4354812 | assay format | Scientific Literature | |
6. | ALA4356134 | Binding | Mixed uncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 2 | ALA4354812 | assay format | Scientific Literature | |
7. | ALA4356137 | Binding | Noncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 3 | ALA4354812 | assay format | Scientific Literature | |
8. | ALA4356139 | Binding | Binding affinity to human IDO2 assessed as change in spectral signal at 200 uM by CPMG NMR spectrometry analysis | Homo sapiens | 2 | ALA4354812 | single protein format | Scientific Literature | |
9. | ALA4356142 | Binding | Binding affinity to human IDO2 at 200 uM by STD NMR spectrometry analysis | Homo sapiens | 2 | ALA4354812 | single protein format | Scientific Literature | |
10. | ALA3872633 | Binding | Competitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of varying concentration of L-tryptophan substrate after 30 mins | Homo sapiens | 2 | ALA3872206 | assay format | Scientific Literature | |
11. | ALA3872634 | Binding | Uncompetitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of varying concentration of L-tryptophan substrate after 30 mins | Homo sapiens | 7 | ALA3872206 | assay format | Scientific Literature | |
12. | ALA3872635 | Binding | Non-competitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of varying concentration of L-tryptophan substrate after 30 mins | Homo sapiens | 1 | ALA3872206 | assay format | Scientific Literature | |
13. | ALA3872636 | Binding | Mixed competitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of varying concentration of L-tryptophan substrate after 30 mins | Homo sapiens | 1 | ALA3872206 | assay format | Scientific Literature | |
14. | ALA3872637 | Binding | Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate after 30 mins in presence of catalase by methylene blue dye based assay | Homo sapiens | 11 | ALA3872206 | assay format | Scientific Literature | |
15. | ALA3872638 | Binding | Potency index, ratio of L-1-methyl-tryptophan Ki to compound Ki for recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 3 | ALA3872206 | assay format | Scientific Literature | |
16. | ALA3872639 | Binding | Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate after 6 hrs by spectrophotometry | Homo sapiens | 11 | ALA3872206 | cell-based format | Scientific Literature | |
17. | ALA3872640 | Binding | Potency index, ratio of D-1-methyl-tryptophan IC50 to compound IC50 for recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 5 | ALA3872206 | assay format | Scientific Literature | |
18. | ALA3872641 | Binding | Reversible inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate after 30 mins | Homo sapiens | 9 | ALA3872206 | assay format | Scientific Literature | |
19. | ALA3872642 | Binding | Potency index, ratio of L-1-methyl-tryptophan IC50 to compound IC50 for recombinant human IDO2 expressed in human U87MG cells | Homo sapiens | 2 | ALA3872206 | cell-based format | Scientific Literature | |
20. | ALA3872643 | Binding | Potency index, ratio of D-1-methyl-tryptophan IC50 to compound IC50 for recombinant human IDO2 expressed in human U87MG cells | Homo sapiens | 6 | ALA3872206 | cell-based format | Scientific Literature |