| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3635348 | B | Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence based assay | Homo sapiens | 18 | ALA3632578 | cell-based format | Scientific Literature | |
| 2. | ALA3635350 | B | Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate | Homo sapiens | 10 | ALA3632578 | single protein format | Scientific Literature | |
| 3. | ALA3635543 | B | Inhibition of MALT1 paracaspase activity in human OCI-LY3 cells assessed as decrease in cleaved CYLD level after 24 hrs by western blot analysis | Homo sapiens | 2 | ALA3632578 | cell-based format | Scientific Literature | |
| 4. | ALA3807229 | B | Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition measured after 60 mins by fluorescence lifetime-based microtitre plate reader analysis | Homo sapiens | 6 | ALA3804826 | single protein format | Scientific Literature | |
| 5. | ALA3807231 | B | Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed by PMA stimulation for 5.5 hrs by luciferase reporter gene assay | Homo sapiens | 6 | ALA3804826 | cell-based format | Scientific Literature | |
| 6. | ALA3816051 | B | Binding affinity to recombinant GST-Malt1 (325 to 760 residues) (unknown origin) assessed as protein labeling at 0.1 to 1 uM after 1 hr by SDS-PAGE based activity-based protein profiling assay | Homo sapiens | 1 | ALA3813635 | single protein format | Scientific Literature | |
| 7. | ALA3816052 | B | Binding affinity to recombinant GST-Malt1 (325 to 760 residues) (unknown origin) assessed as protein labeling at 0.05 to 0.5 uM after 1 hr by SDS-PAGE based activity-based protein profiling assay | Homo sapiens | 1 | ALA3813635 | single protein format | Scientific Literature | |
| 8. | ALA3816053 | B | Binding affinity to recombinant GST-Malt1 (325 to 760 residues) (unknown origin) assessed as protein labeling at 1 uM after 1 hr by SDS-PAGE based activity-based protein profiling assay | Homo sapiens | 2 | ALA3813635 | single protein format | Scientific Literature | |
| 9. | ALA3816054 | B | Binding affinity to Malt1 in phorbol 12-myristate 13-acetate/ionomycin stimulated human Jurkat T cells assessed as protein labeling at 1 uM after 50 mins by SDS-PAGE based activity-based protein profiling assay | Homo sapiens | 2 | ALA3813635 | cell-based format | Scientific Literature | |
| 10. | ALA3816055 | B | Binding affinity to Malt1 in phorbol 12-myristate 13-acetate/ionomycin stimulated human Jurkat T cells assessed as protein labeling at 3 uM after 50 mins by SDS-PAGE based activity-based protein profiling assay | Homo sapiens | 1 | ALA3813635 | cell-based format | Scientific Literature | |
| 11. | ALA3816056 | B | Binding affinity to Flag-tagged Malt1 (unknown origin) overexpressed in human Jurkat T cells assessed as protein labeling at 1 uM after 50 mins by Western blot analysis | Homo sapiens | 3 | ALA3813635 | cell-based format | Scientific Literature | |
| 12. | ALA3816058 | B | Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphenyl)-5H-4l4,5l4-dipyrrolo[1,2-c:20,10-f][1,3,2]diazaborinin-10-yl)butyl)-1H-1,2,3-triazol-1-yl)hexanoyl)-L-valyl-L-arginyl)-N-((S)-1-fluoro-6-guanidino-2-oxohexan-3-yl)pyrrolidine-2-carboxamide addition and incubated for 1 hr by SDS-PAGE based competitive activity-based protein profiling assay | Homo sapiens | 19 | ALA3813635 | single protein format | Scientific Literature | |
| 13. | ALA3816059 | B | Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphenyl)-5H-4l4,5l4-dipyrrolo[1,2-c:20,10-f][1,3,2]diazaborinin-10-yl)butyl)-1H-1,2,3-triazol-1-yl)hexanoyl)-L-valyl-L-arginyl)-N-((S)-1-fluoro-6-guanidino-2-oxohexan-3-yl)pyrrolidine-2-carboxamide addition and incubated for 1 hr by SDS-PAGE based competitive activity-based protein profiling assay | Homo sapiens | 5 | ALA3813635 | single protein format | Scientific Literature | |
| 14. | ALA3816158 | B | Binding affinity to Malt1 in phorbol 12-myristate 13-acetate/ionomycin stimulated human Jurkat T cells assessed as protein labeling at 1 to 3 uM after 50 mins by SDS-PAGE based activity-based protein profiling assay | Homo sapiens | 1 | ALA3813635 | cell-based format | Scientific Literature | |
| 15. | ALA3816159 | B | Inhibition of recombinant full length GST-MALT1 (unknown origin) expressed in Escherichia coli using Ac-LRSR-AMC as substrate by fluorescence analysis | Homo sapiens | 1 | ALA3813635 | assay format | Scientific Literature | |
| 16. | ALA3816160 | B | Inhibition of GST-MALT1 (325 to 760 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence analysis | Homo sapiens | 1 | ALA3813635 | single protein format | Scientific Literature | |
| 17. | ALA4122823 | B | Inhibition of MALT1 in PMA/ionomycin-stimulated human Jurkat T cells assessed as reduction in RelB cleavage at 2 uM pretreated for 4 hrs followed by 1 hr incubation with protease inhibitor MG132 and subsequent PMA/ionomycin-stimulation measured after 1 hr by Western blot analysis | Homo sapiens | 7 | ALA4118168 | cell-based format | Scientific Literature | |
| 18. | ALA4122924 | B | Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg'Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition measured after 60 mins by fluorescence assay | Homo sapiens | 21 | ALA4118176 | single protein format | Scientific Literature | |
| 19. | ALA4122925 | B | Inhibition of cIAP2 fused MALT1 (unknown origin) expressed in HEK293 cells assessed as suppression of NF-kB activation after 24 hrs by luciferase reporter gene assay | Homo sapiens | 21 | ALA4118176 | cell-based format | Scientific Literature | |
| 20. | ALA4122926 | B | Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISA | Homo sapiens | 18 | ALA4118176 | cell-based format | Scientific Literature |
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