| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA960697 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to debrisoquine in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 2. | ALA963151 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to guanabenz in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 3. | ALA1014425 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to melagatran in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 4. | ALA1014426 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to diminazene in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 5. | ALA1014427 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to diminazene monoamidoxime in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 6. | ALA1014428 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to pentamidine monoamidoxime in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 7. | ALA1014429 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to pentamidine in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 8. | ALA1014430 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to benzamidine in reconstituted system containing microsomal cyt b5 and NADH without microsomal NADH cytochrome b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 9. | ALA1014431 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to benzamidine in reconstituted system containing NADH and microsomal NADH cyt b5 reductase without microsomal cytochrome b5 per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 10. | ALA1014432 | B | Specific activity at molybdenum cofactor/metal-free precursor molybopterin bound human recombinant mARC1 expressed in Escherichia coli TP1000 assessed as reduction to benzamidine in complete reconstituted system containing microsomal cyt b5, NADH and microsomal NADH cyt b5 reductase per mg of protein at 0.5 mM by HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 11. | ALA1686549 | U | Activation of prodrug into benzamidine per mg of recombinant hmARC1 in 20 mM MES buffer of pH 6.0 for 30 mins | 1 | assay format | Scientific Literature | |||
| 12. | ALA1686550 | U | Activation of prodrug into pentamidine per mg of recombinant hmARC1 in 20 mM MES buffer of pH 6.0 for 30 mins | 1 | assay format | Scientific Literature | |||
| 13. | ALA4380148 | A | Substrate activity at human recombinant mARC1 expressed in Escherichia coli assessed as enzyme-mediated N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine formation at 3 mM and pH 6 preincubated for 3 mins followed by NADH addition measured after 20 mins under aerobic conditions by RP-HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4614164 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 3 mM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by UV-Visible spectroscopy based NADH assay | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 15. | ALA4614165 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 200 uM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by UV-Visible spectroscopy based NADH assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 16. | ALA4614166 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 500 uM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by UV-Visible spectroscopy based NADH assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 17. | ALA4614167 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 1 mM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by UV-Visible spectroscopy based NADH assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 18. | ALA4614168 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 160 uM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by UV-Visible spectroscopy based NADH assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4614174 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 3 mM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by LC-MS analysis based assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 20. | ALA4614175 | A | Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover rates at 200 uM pre-incubated for 3 mins followed by NADH addition and measured after 15 mins by LC-MS analysis based assay | Homo sapiens | 3 | assay format | Scientific Literature |
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