# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3578794 | Functional | Mitochondrial uncoupling activity in HEK293T/17 cells at 50 uM after 30 mins by TMRE staining-based fluorescence assay | Homo sapiens | 9 | ALA3576830 | cell-based format | Scientific Literature | |
2. | ALA3578892 | ADME | Cytotoxicity against HEK293T/17 cells at 5 uM after 0.5 to 24 hrs by MTS assay | Homo sapiens | 3 | ALA3576830 | cell-based format | Scientific Literature | |
3. | ALA3580292 | ADME | Cytotoxicity against human HEK293T cells assessed as decrease in cell viability by MTT assay | Homo sapiens | 37 | ALA3576796 | cell-based format | Scientific Literature | |
4. | ALA3580327 | ADME | Cytotoxicity against human HEK293T cells at 0.001 to 100 uM after 48 hrs by MTT assay | Homo sapiens | 2 | ALA3576762 | cell-based format | Scientific Literature | |
5. | ALA3583320 | Functional | Cytotoxicity against human HEK293T cells assessed as cell death by MTT assay | Homo sapiens | 21 | ALA3580592 | cell-based format | Scientific Literature | |
6. | ALA3583325 | Functional | Cytotoxicity against human HEK293T cells assessed as cell death after 24 hrs by MTT assay | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
7. | ALA3583326 | Functional | Cytotoxicity against human HEK293T cells assessed as cell death after 48 hrs by MTT assay | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
8. | ALA3585078 | Functional | Cytotoxicity against human HEK293T cells assessed as inhibition of colony formation at LC50 after 24 hrs by crystal violet staining based clonogenic cell survival assay | Homo sapiens | 4 | ALA3580592 | cell-based format | Scientific Literature | |
9. | ALA3585080 | Functional | Induction of cell cycle arrest in HEK293T cells assessed as cells accumulation at G2/M phase at LC50 after 24 hrs by PI staining-based FACS scan flow cytometry (Rvb = 22.2 +/- 1.5%) | Homo sapiens | 4 | ALA3580592 | cell-based format | Scientific Literature | |
10. | ALA3585081 | Functional | Induction of apoptosis in HEK293T cells assessed as chromatin condensation and nuclear fragmentation at LC50 after 24 hrs by DAPI staining-based fluorescent microscopy | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
11. | ALA3585082 | Functional | Induction of apoptosis in HEK293T cells assessed as apoptotic nuclei at LC50 after 24 hrs by DAPI staining-based fluorescent microscopy | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
12. | ALA3585083 | Functional | Induction of apoptosis in HEK293T cells assessed as increase in p53 expression at LC50 after 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
13. | ALA3585084 | Functional | Induction of apoptosis in HEK293T cells assessed as reduction in PARP level at LC50 after 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
14. | ALA3585085 | Functional | Induction of apoptosis in HEK293T cells assessed as activation of caspase 3 at LC50 after 24 hrs by immunocytochemical analysis | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
15. | ALA3585086 | Functional | Induction of DNA damage in HEK293T cells assessed as increase in comet length at LC50 after 24 hrs by Comet assay relative to untreated control | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
16. | ALA3585087 | Functional | Induction of chromosomal damage in HEK293T cells assessed as micronuclei formation at LC50 after 24 hrs by cytokinesis-block micronucleus assay relative to untreated control | Homo sapiens | 5 | ALA3580592 | cell-based format | Scientific Literature | |
17. | ALA3584616 | ADME | Cytotoxicity against HEK293T cells assessed as cell viability after 24 hrs by fluorescence assay | Homo sapiens | 3 | ALA3580635 | cell-based format | Scientific Literature | |
18. | ALA3590876 | Functional | Inhibition of de novo pyrimidine biosynthesis in HEK293T cells assessed as ATP content at 0.016 nM incubated for 24 hrs by ion-pair reversed-phase HPLC method relative to DMSO control | Homo sapiens | 1 | ALA3588748 | cell-based format | Scientific Literature | |
19. | ALA3590877 | Functional | Inhibition of de novo pyrimidine biosynthesis in HEK293T cells assessed as GTP content at 0.016 nM incubated for 24 hrs by ion-pair reversed-phase HPLC method relative to DMSO control | Homo sapiens | 1 | ALA3588748 | cell-based format | Scientific Literature | |
20. | ALA3590878 | Functional | Inhibition of de novo pyrimidine biosynthesis in HEK293T cells assessed as CTP content at 0.016 nM incubated for 24 hrs by ion-pair reversed-phase HPLC method relative to DMSO control | Homo sapiens | 1 | ALA3588748 | cell-based format | Scientific Literature |